Studies of radiation induced peroxidation in fatty acid micelles
Studies of irradiation induced lipid peroxidation in fatty acid micelles, both from our own lab and others, are briefly summarized. Steady state measurements have shown the dependence of hydroperoxide yield on the state of aggregation in the lipid and the degree to which the reactive sites are close packed. Chromatographic measurements obeyed the square root dependence of yield on dose rate confirming the proposed chain mechanism. Application to antioxidant studies have demonstrated the highly efficient blockage of the peroxidation chain by ..cap alpha..-tocopherol and the subsequent prooxidant effect of the product formed. Time resolved studies have been used to determine rate information for .OH-lipid interaction, radical transfer within the lipid, radical peroxidation, lipid radical movement across the micellar boundary, chain termination, and radical interaction with ..cap alpha..-tocopherol. Complimentary laser studies have demonstrated, in contrast to .OH behavior, the comparatively high degree of selectively exhibited by alkoxy radicals toward allylic lipid sites.
- Research Organization:
- Notre Dame Univ., IN (USA). Radiation Lab.
- DOE Contract Number:
- AC02-76ER00038
- OSTI ID:
- 5237370
- Report Number(s):
- NDRL-2107; CONF-800591-1; TRN: 80-012818
- Resource Relation:
- Conference: International conference on oxygen and oxy-radicals in chemistry and biology, Austin, TX, USA, 26 May 1980
- Country of Publication:
- United States
- Language:
- English
Similar Records
An in vitro model to test relative antioxidant potential: Ultraviolet-induced lipid peroxidation in liposomes
Peroxidation of the dried thin film of lipid by high-energy alpha particles from a cyclotron
Related Subjects
CARBOXYLIC ACIDS
PEROXIDES
PEROXIDASES
RADIOINDUCTION
ENZYMES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PORPHYRINS
560111* - Radiation Effects on Biochemicals- In Vitro- (-1987)