A review of environmental and health risks of maleic hydrazide

Journal Article · Tue Mar 01 00:00:00 EST 1983 · Regul. Toxicol. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0273-2300(83)90048-X· OSTI ID:5233631

Ponnampalam, R; Mondy, N I; Babish, J G

The cellular metabolism, acute toxicity, mutagenicity, and carcinogenicity of maleic hydrazide have been reviewed. It seems that this chemical is a mutagen and a carcinogen in cell cultures and animals, but no evidence is available on human carcinogenicity regardless of population exposure in manufacturing, agriculture, and the food chain (i.e., potatoes, potato chips). Because of the level of exposure of the general public to this compound, an epidemiologic survey should be conducted to ascertain possible human health effects. Long-term feeding experiments should be conducted in several animal species to establish whether maleic hydrazide is carcinogenic by this route. Biotransformation and pharmacokinetic studies should be undertaken to obtain better understanding of the chemical's metabolism and excretion. Such investigations would firmly establish whether the tolerance for maleic hydrazide should remain unchanged or whether the use of the compound should be more restricted.

• Research Organization: Department of Preventive Medicine, NYS College of Veterinary Medicine, Cornell University, Ithaca
• OSTI ID: 5233631
• Journal Information: Regul. Toxicol. Pharmacol.; (United States), Vol. 3:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYDRAZIDES
CARCINOGENESIS
METABOLISM
MUTAGENESIS
TOXICITY
CELL CULTURES
FOOD CHAINS
HEALTH HAZARDS
MALEIC ACID
PESTICIDES
RABBITS
ANIMALS
CARBOXYLIC ACIDS
DICARBOXYLIC ACIDS
HAZARDS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology