Effects of inhalation of organic chemical air contaminants on murine lung host defenses

Journal Article · Thu May 01 00:00:00 EDT 1986 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(86)90184-3· OSTI ID:5229820

Aranyi, C; O'Shea, W J; Graham, J A; Miller, F J

The potential health hazards of exposure to threshold limit value (TLV) concentrations of acetaldehyde, acrolein, propylene oxide, chloroform, methyl chloroform, carbon tetrachloride, allyl chloride, methylene chloride, ethylene trichloride, perchloroethylene, benzene, phenol, monochlorobenzene, and benzyl chloride, compounds which may be present in the ambient or work room atmosphere were investigated. The effects of single and multiple 3-hr inhalation exposures were evaluated in mice by monitoring changes in their susceptibility to experimentally induced streptococcus aerosol infection and pulmonary bactericidal activity to inhaled Klebsiella pneumoniae. When significant changes in these parameters were found, further exposures were performed at reduced vapor concentrations until the no-measurable-effect level was reached. Multiple exposures on 5 consecutive days were then performed at this concentration. Significant increases in susceptibility to respiratory streptococcus infection were observed after single 3-hr exposure to TLV concentrations of methylene chloride, perchloroethylene, and ethylene trichloride. For methylene chloride and perchloroethylene, these exposure conditions also resulted in significantly decreased pulmonary bactericidal activity.

• Research Organization: IIT Research Institute, Chicago, IL
• OSTI ID: 5229820
• Journal Information: Fundam. Appl. Toxicol.; (United States), Vol. 4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACROLEIN
BIOLOGICAL EFFECTS
BENZENE
CARBON TETRACHLORIDE
CHLOROFORM
KLEBSIELLA
INFECTIVITY
METHYLENE CHLORIDE
ORGANIC CHLORINE COMPOUNDS
PHENOLS
STREPTOCOCCUS
AIR POLLUTION
INHALATION
LUNGS
MACROPHAGES
MICE
PHAGOCYTOSIS
ALDEHYDES
ANIMAL CELLS
ANIMALS
AROMATICS
BACTERIA
BODY
CHLORINATED ALIPHATIC HYDROCARBONS
CONNECTIVE TISSUE CELLS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROCARBONS
HYDROXY COMPOUNDS
INTAKE
MAMMALS
MICROORGANISMS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PHAGOCYTES
POLLUTION
RESPIRATORY SYSTEM
RODENTS
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)