Metabolism in the rat of cadmium biocomplexes from edible mussels exposed to /sup 109/CdCl/sub 2/
The metabolism in the rat of /sup 109/Cd biocomplexes present in the tissues of the edible mussel Mytilus galloprovincialis, previously exposed to /sup 109/CdCl/sub 2/, was studied. The tissue distribution and binding of /sup 109/Cd were compared to those caused by an equal dose of /sup 109/Cd as CdCl2 or rat liver Cd-metallothionein. Administration of mussel /sup 109/Cd to rats resulted in an initial accumulation of /sup 109/Cd in the kidneys due to the presence of /sup 109/Cd-metallothionein, which constituted 25% of the /sup 109/Cd in the tissues of the mussels. Other /sup 109/Cd biocomplexes present in the mussel tissues were metabolized in the rat in a way similar to that of inorganic cadmium, i.e., initial accumulation in the liver. These findings indicate that the ingestion of seafood rich in metallothionein may give rise to a faster increase of renal cadmium levels than the consumption of a similar amount of inorganic cadmium.
- Research Organization:
- Commission of the European Communities, Ispra, Italy
- OSTI ID:
- 5229235
- Journal Information:
- Ecotoxicol. Environ. Saf.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Tissue- and cell-specific expression of metallothionein genes in cadmium- and copper-exposed mussels analyzed by in situ hybridization and RT-PCR
Heavy metals in blue mussels (mytilus edulis) in the Bergen Harbor area, Western Norway
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
METABOLISM
TISSUE DISTRIBUTION
FOOD CHAINS
CONTAMINATION
BIOLOGICAL ACCUMULATION
CADMIUM 109
FECES
KIDNEYS
LABELLED COMPOUNDS
LIVER
METABOLIC ACTIVATION
METALLOTHIONEIN
MUSSELS
RATS
TRACER TECHNIQUES
WATER POLLUTION
ANIMALS
AQUATIC ORGANISMS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CADMIUM ISOTOPES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
INVERTEBRATES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
METALLOPROTEINS
METALS
MOLLUSCS
NUCLEI
ORGANIC COMPOUNDS
ORGANS
POLLUTION
PROTEINS
RADIOISOTOPES
RODENTS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
550501* - Metabolism- Tracer Techniques
560304 - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)