Noninvasive measurement of liver regeneration with positron emission tomography and (2-11C)thymidine

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Gastroenterology; (United States)

OSTI ID:5229140

Vander Borght, T; Lambotte, L; Pauwels, S; Labar, D; Beckers, C; Dive, C ^[1]

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1. University of Louvain Medical School, Brussels (Belgium)

The feasibility of liver regeneration determination with (2-11C)thymidine and positron emission tomography was investigated in partially hepatectomized rats. Serial tomographic scans were performed over a 120-minute period after injection of (2-11C)thymidine together with tritium-labeled thymidine. Within 10 minutes after injection, positron emission tomography scans showed a twofold higher hepatic uptake in regenerating than in nonregenerating livers. Time-activity curves over the liver area indicated that the maximal uptake was followed by a faster decrease of 11C radioactivity in controls than in regenerating animals, so that total 11C activity remaining in the liver at 120 minutes accounted for 68% of maximum in regenerating and only 38% in controls. Tissue distribution studies performed at 120 minutes showed that total 11C radioactivity, expressed in percent injected dose per gram, was six times higher in regenerating livers than in controls (0.62% {plus minus} 0.07% in regenerating livers and 0.10% {plus minus} 0.03% in nonregenerating livers; P less than 0.001) and correlated with 3H radioactivity measured in the nuclear fraction (r = 0.92; P less than 0.001). When the hepatic uptake was expressed in percent of dose per organ, the difference between both groups increased (2.31% {plus minus} 0.23% in regenerating livers and 0.29% {plus minus} 0.02% in nonregenerating livers; P less than 0.001) because of higher weight of regenerating livers than of nonregenerating livers (3.83 {plus minus} 0.11 g in regenerating livers and 2.96 {plus minus} 0.16 g in nonregenerating livers; P less than 0.001). In other organs examined, no difference in 11C radioactivity was found between the two groups of rats. These results indicated the potential usefulness of (2-11C)thymidine and positron emission tomography for noninvasive measurement of liver regeneration.

• OSTI ID: 5229140
• Journal Information: Gastroenterology; (United States), Vol. 101:3; ISSN 0016-5085
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LIVER
BIOLOGICAL REGENERATION
CARBON 11
POSITRON COMPUTED TOMOGRAPHY
RATS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AZINES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL RECOVERY
BODY
CARBON ISOTOPES
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIOISOTOPES
RECOVERY
RIBOSIDES
RODENTS
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics