Cardiac output by Doppler echocardiography in the premature baboon: Comparison with radiolabeled microspheres

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Pediatric Cardiology; (United States)

DOI:https://doi.org/10.1007/BF02238410· OSTI ID:5229097

Kinsella, J P; Morrow, W R; Gerstmann, D R; Taylor, A F; deLemos, R A ^[1]

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1. Wilford Hall U.S.A.F. Medical Center, San Antonio, TX (USA)

Pulsed-Doppler echocardiography (PDE) is a useful noninvasive method for determining left ventricular output (LVO). However, despite increasingly widespread use in neonatal intensive care units, validation studies in prematures with cardiopulmonary disease are lacking. The purpose of this study was to compare radiolabeled microsphere (RLM) and PDE measurements of LVO, using the critically ill premature baboon as a model of the human neonate. Twenty-two paired RLM and PDE measurements of LVO were obtained in 14 animals between 3 and 24 h of age. Average PDE LVO was 152 ml/min/kg (range, 40-258 ml/min/kg) compared to 158 ml/min/kg (range, 67-278 ml/min/kg) measured by RLM. Linear regression analysis of the paired measurements showed good correlation with a slope near unity (gamma = 0.94x + 4.20, r = 0.91, SEE = 25.7 ml). The authors conclude that PDE determinations of LVO compare well with those measured by RLM in the premature baboon. PDE appears to provide a valid estimate of LVO and should be useful in human prematures with cardiopulmonary distress.

• OSTI ID: 5229097
• Journal Information: Pediatric Cardiology; (United States), Vol. 12:2; ISSN 0172-0643
• Country of Publication: United States
• Language: English

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