Collagen macromolecular drug delivery systems
Abstract
The objective of this study was to examine collagen for use as a macromolecular drug delivery system by determining the mechanism of release through a matrix. Collagen membranes varying in porosity, crosslinking density, structure and crosslinker were fabricated. Collagen characterized by infrared spectroscopy and solution viscosity was determined to be pure and native. The collagen membranes were determined to possess native vs. non-native quaternary structure and porous vs. dense aggregate membranes by electron microscopy. Collagen monolithic devices containing a model macromolecule (inulin) were fabricated. In vitro release rates were found to be linear with respect to t{sup {1/2}} and were affected by crosslinking density, crosslinker and structure. The biodegradation of the collagen matrix was also examined. In vivo biocompatibility, degradation and {sup 14}C-inulin release rates were evaluated subcutaneously in rats.
- Authors:
- Publication Date:
- Research Org.:
- Utah Univ., Salt Lake City, UT (USA)
- OSTI Identifier:
- 5228916
- Resource Type:
- Thesis/Dissertation
- Resource Relation:
- Other Information: Thesis (Ph. D.)
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; COLLAGEN; MEMBRANE TRANSPORT; DRUGS; CARBON 14 COMPOUNDS; CELL MEMBRANES; CHEMICAL COMPOSITION; CROSS-LINKING; ELECTRON MICROSCOPY; INFRARED SPECTRA; INULIN; METABOLISM; MOLECULAR STRUCTURE; RATS; TRACER TECHNIQUES; ANIMALS; CARBOHYDRATES; CELL CONSTITUENTS; CHEMICAL REACTIONS; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MEMBRANES; MICROSCOPY; ORGANIC COMPOUNDS; POLYMERIZATION; POLYSACCHARIDES; PROTEINS; RODENTS; SACCHARIDES; SCLEROPROTEINS; SPECTRA; VERTEBRATES; 550201* - Biochemistry- Tracer Techniques
Citation Formats
Gilbert, D L. Collagen macromolecular drug delivery systems. United States: N. p., 1988.
Web.
Gilbert, D L. Collagen macromolecular drug delivery systems. United States.
Gilbert, D L. 1988.
"Collagen macromolecular drug delivery systems". United States.
@article{osti_5228916,
title = {Collagen macromolecular drug delivery systems},
author = {Gilbert, D L},
abstractNote = {The objective of this study was to examine collagen for use as a macromolecular drug delivery system by determining the mechanism of release through a matrix. Collagen membranes varying in porosity, crosslinking density, structure and crosslinker were fabricated. Collagen characterized by infrared spectroscopy and solution viscosity was determined to be pure and native. The collagen membranes were determined to possess native vs. non-native quaternary structure and porous vs. dense aggregate membranes by electron microscopy. Collagen monolithic devices containing a model macromolecule (inulin) were fabricated. In vitro release rates were found to be linear with respect to t{sup {1/2}} and were affected by crosslinking density, crosslinker and structure. The biodegradation of the collagen matrix was also examined. In vivo biocompatibility, degradation and {sup 14}C-inulin release rates were evaluated subcutaneously in rats.},
doi = {},
url = {https://www.osti.gov/biblio/5228916},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}