Toxicology of chemical mixtures: Experimental approaches, underlying concepts, and some results
The toxicology of chemical mixtures will be the toxicology of the 1990s and beyond. While this branch of toxicology most closely reflects the actual human exposure situation, as yet there is no standard protocol or consensus methodology for investigating the toxicology of mixtures. Thus, in this emerging science, experimentation is required just to develop a broadly applicable evaluation system. Several examples are discussed to illustrate the different experimental designs and the concepts behind each. These include the health effects studies of Love Canal soil samples, the Lake Ontario Coho salmon, the water samples repurified from secondary sewage in the city of Denver Potable Water Reuse Demonstration Plant, and the National Toxicology Program (NTP) effort on a mixture of 25 frequently detected groundwater contaminants derived from hazardous waste disposal sites. In the last instance, an extensive research program has been ongoing for the last two years at the NTP, encompassing general toxicology, immunotoxicology, developmental and reproductive toxicology, biochemical toxicology, myelotoxicology, genetic toxicology, neurobehavioral toxicology, and hepato- and renal toxicology.
- Research Organization:
- National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States)
- OSTI ID:
- 5227172
- Report Number(s):
- AD-P-006359/4/XAB
- Resource Relation:
- Other Information: This article is from Proceedings of the Conference on Toxicology (18th) Held in Dayton, Ohio on 1-3 November 1988, AD-A235 912, p103-118
- Country of Publication:
- United States
- Language:
- English
Similar Records
Regulation of priority carcinogens and reproductive or developmental toxicants
Umatilla Hatchery Satellite Facilities; Operations and Maintenance, Annual Report 2001.
Related Subjects
XENOBIOTICS
TOXICITY
COLORADO
GENETICS
LAKE ONTARIO
MAN
MIXTURES
SALMON
SEWAGE
SOILS
STANDARDS
URBAN AREAS
WASTE DISPOSAL
ANADROMOUS FISHES
ANIMALS
AQUATIC ORGANISMS
BIOLOGY
DEVELOPED COUNTRIES
DISPERSIONS
FEDERAL REGION VIII
FISHES
GREAT LAKES
LAKES
MAMMALS
MANAGEMENT
NORTH AMERICA
PRIMATES
SURFACE WATERS
USA
VERTEBRATES
WASTE MANAGEMENT
WASTES
560300* - Chemicals Metabolism & Toxicology