Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras

Journal Article · Sun Sep 01 00:00:00 EDT 1991 · Cellular Immunology; (United States)

DOI:https://doi.org/10.1016/0008-8749(91)90352-C· OSTI ID:5227095

van Bruggen, M C; van den Broek, M F; van den Berg, W B ^[1]

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1. University Hospital Nijmegen, (Netherlands)

Streptococcal cell wall (SCW)-induced arthritis and adjuvant arthritis (AA) are rat models for chronic, erosive polyarthritis. Both models can be induced in susceptible Lewis rats, whereas F344 rats are resistant. In AA as well as in SCW arthritis, antigen-specific T lymphocytes have been demonstrated to be crucial for chronic disease. In this communication the authors describe their studies to probe the cellular mechanism responsible for the difference in susceptibility of Lewis and F344, using bone marrow chimeras. By transplanting bone marrow cells from F344 into lethally irradiated Lewis recipients, Lewis rats were rendered resistant to SCW arthritis induction. F344 rats reconstituted with Lewis bone marrow, i.e., Lewis----F344 chimeras, develop an arthritis upon SCW injection. For AA comparable results were obtained. These data suggest that both resistance and susceptibility to bacterium-induced chronic arthritis are mediated by hemopoietic/immune cells and that the recipiental environment does not influence the susceptibility to chronic joint inflammation.

• OSTI ID: 5227095
• Journal Information: Cellular Immunology; (United States), Vol. 136:2; ISSN 0008-8749
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
TRANSPLANTS
IMMUNITY
RADIOINDUCTION
CELL WALL
DISEASE RESISTANCE
RADIATION CHIMERAS
RATS
RHEUMATIC DISEASES
STREPTOCOCCUS
ANIMAL CELLS
ANIMALS
BACTERIA
CELL CONSTITUENTS
CHIMERAS
CONNECTIVE TISSUE CELLS
DISEASES
MAMMALS
MICROORGANISMS
MOSAICISM
RODENTS
SKELETAL DISEASES
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals