Monoclonal antibodies reactive with human breast or ovarian carcinoma: In vivo applications

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Seminars in Nuclear Medicine; (USA)

DOI:https://doi.org/10.1016/S0001-2998(89)80022-4· OSTI ID:5226439

Thor, A D; Edgerton, S M ^[1]

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1. Harvard Medical School, Boston, MA (USA)

Monoclonal antibodies (MoAbs) are unique and useful bioprobes that allow in vivo targeting of membrane-associated or circulating antigens. Most of the clinical trials to date have used low dosages of radiolabeled MoAb given in a single dose. Newer studies have included antibody fragments, repeated injections, intraperitoneal (IP) administration, and other labels such as 90Y. Clinical MoAb trials are often arduous, expensive, and time-consuming to perform. Before human use, animal studies and extensive MoAb characterization are required. The production of pharmaceutical grade, radiolabeled MoAb is technically difficult and costly. Clinical trials require administrative and patient consent as well as extensive written protocols. These studies necessitate interdepartmental and intradepartmental cooperation and coordination. Furthermore, the use of in vivo radiolabeled probes impacts many levels of health care providers from janitorial, nursing, and technical staff to laboratories and physicians. Simple blood tests or disposal of body excretions may concern nursing or technical staff with the possibility of radiation exposure. The responsibility for study design, personnel involvement, and prospective use in patients without a definitive cancer diagnosis ultimately rests with the physician. While many issues have been addressed, additional clinical trials, consideration of safety issues, and standardization between institutions will be necessary before the use of radiolabeled MoAb for diagnosis, management, or therapy of human tumors becomes routine. Continued cooperation and funding should ensure its achievement. 136 references.

• OSTI ID: 5226439
• Journal Information: Seminars in Nuclear Medicine; (USA), Vol. 19:4; ISSN 0001-2998
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
CARCINOMAS
DIAGNOSIS
IMMUNOTHERAPY
RADIOIMMUNOTHERAPY
RADIOTHERAPY
MAMMARY GLANDS
MONOCLONAL ANTIBODIES
SPECIFICITY
OVARIES
MAN
RADIOIMMUNOSCINTIGRAPHY
REVIEWS
ANIMALS
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DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
FEMALE GENITALS
GLANDS
GONADS
IMMUNOLOGY
ISOTOPE APPLICATIONS
MAMMALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PRIMATES
RADIOIMMUNODETECTION
RADIOIMMUNOLOGY
RADIOISOTOPE SCANNING
RADIOLOGY
SCINTISCANNING
THERAPY
TRACER TECHNIQUES
VERTEBRATES
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