Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985

Crocker, T T; Bhalla, D K

Title: Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985

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Abstract

The study analyzed rats' nasal, tracheal and bronchoalveolar epithelial permeability to macromolecules after they were exposed, in 2- or 4-hour periods of rest or exercise, to ozone (O/sub 3/)(0.6, 0.8 or 2 ppm), nitrogen dioxide (NO/sub 2/)(2.5, 6 or 12 ppm) or formaldehyde (10 ppm). Exercise was performed on a treadmill operated at a speed that led to a 2-fold increase in oxygen consumption. Histopathologic and electron-microscopic cytochemical and autoradiographic studies were performed to identify the structural aspects of mucosal response. Results indicate that different air pollutants affect different sites in the respiratory tract with respect to epithelial permeability to macromolecules.

Authors:: Crocker, T T; Bhalla, D K

Publication Date:: Wed Jan 01 00:00:00 EST 1986

Research Org.:: Health Effects Inst., Cambridge, MA (USA); California Univ., Irvine (USA)

OSTI Identifier:: 5222692

Report Number(s):: PB-86-209855/XAB

Resource Type:: Technical Report

Resource Relation:: Other Information: Prepared in cooperation with California Univ., Irvine

Country of Publication:: United States

Language:: English

Subject:: 54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; FORMALDEHYDE; BIOLOGICAL EFFECTS; NITROGEN DIOXIDE; OZONE; RESPIRATORY SYSTEM; HEALTH HAZARDS; MICE; RESPIRATION; ALDEHYDES; ANIMALS; CHALCOGENIDES; HAZARDS; MAMMALS; NITROGEN COMPOUNDS; NITROGEN OXIDES; ORGANIC COMPOUNDS; OXIDES; OXYGEN COMPOUNDS; RODENTS; VERTEBRATES; 500200* - Environment, Atmospheric- Chemicals Monitoring & Transport- (-1989); 560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

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                    Crocker, T T, and Bhalla, D K. Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985.  United States: N. p., 1986. 
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                    Crocker, T T, & Bhalla, D K. Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985.  United States.

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                    Crocker, T T, and Bhalla, D K. 1986.  
        "Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985".  United States.

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@article{osti_5222692,

  title        = {Transport of macromolecules and particles at target sites for deposition of air pollutants. Report for 1 August 1983-31 July 1985},

  author       = {Crocker, T T and Bhalla, D K},

  abstractNote = {The study analyzed rats' nasal, tracheal and bronchoalveolar epithelial permeability to macromolecules after they were exposed, in 2- or 4-hour periods of rest or exercise, to ozone (O/sub 3/)(0.6, 0.8 or 2 ppm), nitrogen dioxide (NO/sub 2/)(2.5, 6 or 12 ppm) or formaldehyde (10 ppm). Exercise was performed on a treadmill operated at a speed that led to a 2-fold increase in oxygen consumption. Histopathologic and electron-microscopic cytochemical and autoradiographic studies were performed to identify the structural aspects of mucosal response. Results indicate that different air pollutants affect different sites in the respiratory tract with respect to epithelial permeability to macromolecules.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5222692},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Wed Jan 01 00:00:00 EST 1986},

  month        = {Wed Jan 01 00:00:00 EST 1986}

}

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