Antigenemia detected by radioimmunoassay in systemic aspergillosis

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-92-6-793· OSTI ID:5220899

Weiner, M H

Because of difficulties in antemortem diagnosis of systemic aspergillosis, a radioimmunoassay to an Aspergillus fumigatus carbohydrate was developed and evaluated in patients with mycotic or bacterial infections. Antigenemia was detected in sera obtained antemortem from four of seven patients with systemic aspergillosis and in pleural fluid from an Aspergillus empyema but not in control sera or pleural fluid from 43 patients or 27 normal donors. When characterized with reference to onset of disease, antigenemia was an early sign of infection. This study shows the usefulness of the Aspergillus antigen radioimmunoassay for early, specific immunodiagnosis of systemic aspergillosis.

• Research Organization: Univ. of Texas Health Science Center, San Antonio
• OSTI ID: 5220899
• Journal Information: Ann. Intern. Med.; (United States), Vol. 92:6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
ANTIGENS
RADIOIMMUNOASSAY
INFECTIOUS DISEASES
DIAGNOSIS
ANTIGEN-ANTIBODY REACTIONS
ASPERGILLUS
CARBOHYDRATES
DIAGNOSTIC USES
IODINE 125
LABELLED COMPOUNDS
PATIENTS
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
FUNGI
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PLANTS
RADIOASSAY
RADIOISOTOPES
TRACER TECHNIQUES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics