Prospective study of the changes in thyrotropin binding inhibitory immunoglobulins in Graves' disease treated by subtotal thyroidectomy or radioactive iodine

Journal Article · Sun Jun 01 00:00:00 EDT 1980 · J. Clin. Endocrinol. Metab.; (United States)

DOI:https://doi.org/10.1210/jcem-50-6-1005· OSTI ID:5220047

Teng, C S; Yeung, R T.T.; Khoo, R K.K.; Alagaratnam, T T

The effects of subtotal thyroidectomy and radioactive iodine on thyroid-stimulating immunoglobulins, as measured by a receptor assay, more appropriately termed TSH binding inhibitory immunoglobulins (TBII), were studied in 74 patients with Graves' disease. Fourty-four patients received radioactive iodine therapy, while 30 were subjected to subtotal thyroidectomy. After radioactive iodine, more patients were TBII-positive (90.5% vs 81.8%) than before treatment, and the mean TBII index decreased dramatically, the maximum decrease being 3 months. The mean TBI index subsequently returned gradually to the pretreatment level. Subtotal thyroidectomy had a different effect on TBII activity. TBII indices were positive in 89.3% of these patients before any treatment but were positive in only 40% (12 patients) after antithyroid drugs had been given before surgery. After surgery, TBII indices remained positive in 7 patients, while the remaining 5 patients became TBII negative. Seventeen patients (56.7%) were TBII negative before operation and remained so after surgery. One patient who was TBII negative before operation became TBII positive 2 months after operation. Interestingly, postoperative relapse of hyperthyroidism occurred in 3 patients who were TIBII positive, while hypothyroidism occurred in patients who were TBII negative. Thus, the TBII activity after subtotal thyroidectomy might be an important factor in determining the outcome of surgery.

• Research Organization: Univ. of Hong Kong
• OSTI ID: 5220047
• Journal Information: J. Clin. Endocrinol. Metab.; (United States), Vol. 50:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
ENDOCRINE DISEASES
RADIOTHERAPY
IMMUNOGLOBULINS
BIOLOGICAL RADIATION EFFECTS
SIDE EFFECTS
THYROID
ANTITHYROID DRUGS
BIOCHEMISTRY
COMPARATIVE EVALUATIONS
INTERNAL IRRADIATION
IODINE 125
PATIENTS
THYROID HORMONES
THYROIDECTOMY
TSH
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CHEMISTRY
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
GLOBULINS
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
IRRADIATION
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
SURGERY
THERAPY
560161* - Radionuclide Effects
Kinetics
& Toxicology- Man
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)