Effect of H-2 complex on the growth of embryo-derived teratomas in mice

Journal Article · Sat Feb 01 00:00:00 EST 1986 · Am. J. Reprod. Immunol. Microbiol.; (United States)

DOI:https://doi.org/10.1111/j.1600-0897.1986.tb00007.x· OSTI ID:5217818

Taya, C; Moriwaki, K

Seven-day-old embryos of several H-2 congenic strains were transplanted under the kidney capsules of syngeneic adult recipients to determine the genetic factors(s) governing the in vivo growth of embryo-derived teratomas. A.TH(H-2t2) and A.TL(H-2t1) strains showed significantly greater tumor weights than A.BY(H-2b) and A.SW(H-2s) strains. The A(H-2a) strain was intermediate in tumor size. A comparison of the genic constitution of the H-2 complex in each congenic strain suggested that the H-2D locus and/or its distal regions affected the growth of embryo-derived teratomas. The teratoma induced in the B10.A(H-2a) strain was smaller than that in the A(H-2a) strain, indicating that the genetic background of the A strain is favorable for teratoma growth. Histological observations demonstrated that the existence of embryonal carcinoma cells was necessary for the growth of teratomas. A radiation-sensitive immunological factor in the recipient probably plays a role in stimulating teratoma growth.

• Research Organization: National Institute of Genetics, Mishima, Japan
• OSTI ID: 5217818
• Journal Information: Am. J. Reprod. Immunol. Microbiol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
NEOPLASMS
MICE
RADIOSENSITIVITY
GROWTH
TRANSPLANTS
EMBRYOS
GENETIC VARIABILITY
IMMUNITY
PREGNANCY
ANIMALS
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BODY
DISEASES
MAMMALS
ORGANS
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals