Inhaled toluene produces pentobarbital-like discriminative stimulus effects in mice

Journal Article · Mon Oct 07 00:00:00 EDT 1985 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(85)90247-4· OSTI ID:5216577

Rees, D C; Coggeshall, E; Balster, R L

The abuse of volatile solvents may be due to their ability to produce an intoxication similar to that produced by classical central nervous system depressants such as the barbiturates and ethanol. To evaluate this hypothesis, mice were trained to discriminate pentobarbital from saline injections in a two-lever operant task. Stimulus generalization was examined following 20-min inhalation exposures to toluene (300-5400 ppm). In 8 of 10 subjects, pentobarbital-lever responding occurred following toluene exposure indicating an overlap in the discriminative stimulus properties of toluene and pentobarbital.

• Research Organization: Virginia Commonwealth Univ., Richmond
• OSTI ID: 5216577
• Journal Information: Life Sci.; (United States), Vol. 37:14
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
TOLUENE
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM
INHALATION
MICE
ORGANIC SOLVENTS
ALKYLATED AROMATICS
ANIMALS
AROMATICS
HYDROCARBONS
INTAKE
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
RODENTS
SOLVENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)