Effect of elevated selenium intakes on mammary cell proliferation in rats

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5212854

Salbe, A D; Albanes, D; Winick, M; Taylor, P R; Levander, O A ^[1]

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1. Dept. of Agriculture, Beltsville, MD (United States) National Institutes of Health, Bethesda, MD (United States)

Elevated selenium (Se) intakes and calorie restriction (CR) inhibit mammary tumorigenesis in experimental animals. The present study was designed to investigate cell proliferation in the mammary tissue gland. Female weanling Sprague-Dawley rats were divided into 4 groups: control, 40% CR, 4 or 6 ppm Se in water as selenate. Control rats and Se rats were fed a control diet ad lib. CR rats were pair-fed 40% less than controls with a diet providing equal nutrients except carbohydrate calories. After 3 weeks, rats were injected with ({sup 3}H)-thymidine and killed 1 hr later. Se at 4 ppm significantly decreased only the number of ducts, whereas 6 ppm Se decreased both the number of ducts as well as the number and percent of labeled cells. CR had no effect on mammary cell proliferation. These results suggest that elevated Se intakes may protect against mammary tumorigenesis by decreasing cell proliferation, a mechanism which may affect the dose-response of the genotoxic chemicals frequently used as initiating agents in animal experiments.

• OSTI ID: 5212854
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
CELL PROLIFERATION
SELENIUM
BIOLOGICAL EFFECTS
INHIBITION
INTAKE
MAMMARY GLANDS
RATS
THYMIDINE
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
AZINES
BODY
ELEMENTS
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
MAMMALS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RIBOSIDES
RODENTS
SEMIMETALS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology