Endothelial cell perturbation and low-density lipoprotein. Quantitative autoradiography

Journal Article · Thu Jan 01 00:00:00 EST 1987 · Ann. N.Y. Acad. Sci.; (United States)

DOI:https://doi.org/10.1111/j.1749-6632.1987.tb33060.x· OSTI ID:5209268

Morrel, E M; Holland, J A; Pritchard, K A; Colton, C K; Stemerman, M B

The focal entry and accumulation of LDL within the arterial wall of the normal animal may represent an early stage in the development of the atherosclerotic plaque. Concentrations of LDL 10 to 100 times normal medial concentrations might be difficult to clear from the arterial wall, permitting accumulation of lipid. Elevated LDL concentrations, in proximity to smooth muscle cells, appear to stimulate SMC proliferation. High LDL concentrations might also enhance mononuclear cell adhesion to endothelium. Since LDL has a high affinity for heparin and heparin for growth factors, LDL accumulation may be a mechanism for the concentration of such materials in the intima. The observation of markedly enhanced macromolecular permeability foci could be related to several potential mechanisms of initiation of atherosclerosis. This observation is of particular note when the focal occurrence of atherosclerosis is considered. Although atherosclerosis is seen as a generalized thickening of the intima, it is the focal narrowing of the lumen that is often responsible for the stenosis which produces symptoms such as angina or myocardial infarction.

• Research Organization: Massachusetts Institute of Technology, Cambridge (USA)
• OSTI ID: 5209268
• Journal Information: Ann. N.Y. Acad. Sci.; (United States), Vol. 516
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ARTERIOSCLEROSIS
PATHOGENESIS
LIPOPROTEINS
AUTORADIOGRAPHY
BIOLOGICAL ACCUMULATION
ADHESION
CELL CULTURES
CELL PROLIFERATION
ENDOTHELIUM
MUSCLES
RABBITS
ANIMAL TISSUES
ANIMALS
BODY
CARDIOVASCULAR DISEASES
DISEASES
LIPIDS
MAMMALS
ORGANIC COMPOUNDS
PROTEINS
TISSUES
VASCULAR DISEASES
VERTEBRATES
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