Comparison of lung vascular and epithelial permeability indices in the adult respiratory distress syndrome

Journal Article · Sun Jun 01 00:00:00 EDT 1986 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5206263

Braude, S; Nolop, K B; Hughes, J M; Barnes, P J; Royston, D

Measurements of pulmonary clearance of inhaled /sup 99m/Tc-DTPA and transvascular 113mIn-transferrin flux were made in 12 patients with established ARDS and 14 volunteer control subjects (7 smokers and 7 nonsmokers). Smokers had significantly increased /sup 99m/Tc-DTPA clearance (clearance rate constant, 3.6 +/- 0.8; mean +/- SEM) compared with nonsmokers (1.2 +/- 0.1). All patients with ARDS had increased clearance of /sup 99m/Tc-DTPA (5.2 +/- 0.9), but the finding was nonspecific in that increased clearance overlapped with the findings in normal smokers. Protein flux in smokers (protein flux units, 0.0 +/- 0.2) was similar to that in nonsmokers (0.3 +/- 0.2). In 9 of the 12 patients with ARDS, protein flux was increased, and as a group (3.2 +/- 1.0) they differed significantly (p less than 0.01) from the combined smoking and nonsmoking control subjects (0.2 +/- 0.1, n = 14). The parameters of DTPA clearance and transvascular protein flux correlated well in the patients with ARDS (Spearman's rank correlation = 0.71, p less than 0.01). Although /sup 99m/Tc-DTPA clearance is a sensitive technique in ARDS, a single study in this context does not allow a diagnostic conclusion because of its non-specificity. Abnormal protein flux appears to be more specific for ARDS but was not a universal finding in the patients studied.

• Research Organization: Royal Postgraduate Medical School, London, England
• OSTI ID: 5206263
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 6
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD VESSELS
PERMEABILITY
DTPA
CLEARANCE
TECHNETIUM 99
EPITHELIUM
INDIUM 113
INHALATION
LUNGS
MEMBRANE TRANSPORT
PROTEINS
RESPIRATORY SYSTEM DISEASES
TRANSFERRIN
AMINO ACIDS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
DISEASES
DRUGS
GLOBULINS
GLOBULINS-BETA
HOURS LIVING RADIOISOTOPES
INDIUM ISOTOPES
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
METALLOPROTEINS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RESPIRATORY SYSTEM
STABLE ISOTOPES
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics