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Title: Dose distribution of neutron beam and chromosome analysis

Abstract

Chromosome analysis using peripheral lymphocytes is a sensitive and reliable indicator of the biological effect of radiation at low radiation doses. In the present study, using this chromosome aberration analysis, we tried to investigate the radiation dose distribution within and around the radiation field of a 6 MeV neutron beam. The efficient induction of dicentrics and rings at the irradiation of neutrons compared to those of gamma or X rays especially in a lower dose range, results in a dominant linear component in the linear quadratic model in the dose response relation of a chromosome aberration formation. A marked increase of RBE (relative biological effectiveness) in a lower dose range of neutrons was demonstrated. The radiation doses of the neutron beam as a function of depth, estimated from the yields of dicentrics and rings in a water phantom revealed a fairly good agreement with doses that were physically obtained. The radiation portal margin of the neutron beam was demonstrated to be not as sharp due to a wide penumbra. This wide penumbra and high RBE value, especially at lower dose range of the neutron beam may contribute to the induction of secondary malignancies in the normal tissue surrounding the tumormore » mass.« less

Authors:
; ; ; ;
Publication Date:
Research Org.:
Tokyo Medical and Dental Univ. (Japan)
OSTI Identifier:
5200126
Resource Type:
Journal Article
Journal Name:
Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Additional Journal Information:
Journal Volume: 14:3
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 61 RADIATION PROTECTION AND DOSIMETRY; CHROMOSOMAL ABERRATIONS; RADIOINDUCTION; LYMPHOCYTES; RADIOSENSITIVITY; NEUTRON BEAMS; RADIATION DOSE DISTRIBUTIONS; DOSE-RESPONSE RELATIONSHIPS; FAST NEUTRONS; GENETIC RADIATION EFFECTS; IN VITRO; LOW DOSE IRRADIATION; PHANTOMS; RBE; WATER; ANIMAL CELLS; BARYONS; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; ELEMENTARY PARTICLES; FERMIONS; GENETIC EFFECTS; HADRONS; HYDROGEN COMPOUNDS; IRRADIATION; LEUKOCYTES; MATERIALS; MOCKUP; MUTATIONS; NEUTRONS; NUCLEON BEAMS; NUCLEONS; OXYGEN COMPOUNDS; PARTICLE BEAMS; RADIATION EFFECTS; SOMATIC CELLS; STRUCTURAL MODELS; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture; 655003 - Medical Physics- Dosimetry

Citation Formats

Matsubara, S, Kuwabara, Y, Horiuchi, J, Suzuki, S, and Ito, A. Dose distribution of neutron beam and chromosome analysis. United States: N. p., 1988. Web. doi:10.1016/0360-3016(88)90267-2.
Matsubara, S, Kuwabara, Y, Horiuchi, J, Suzuki, S, & Ito, A. Dose distribution of neutron beam and chromosome analysis. United States. https://doi.org/10.1016/0360-3016(88)90267-2
Matsubara, S, Kuwabara, Y, Horiuchi, J, Suzuki, S, and Ito, A. 1988. "Dose distribution of neutron beam and chromosome analysis". United States. https://doi.org/10.1016/0360-3016(88)90267-2.
@article{osti_5200126,
title = {Dose distribution of neutron beam and chromosome analysis},
author = {Matsubara, S and Kuwabara, Y and Horiuchi, J and Suzuki, S and Ito, A},
abstractNote = {Chromosome analysis using peripheral lymphocytes is a sensitive and reliable indicator of the biological effect of radiation at low radiation doses. In the present study, using this chromosome aberration analysis, we tried to investigate the radiation dose distribution within and around the radiation field of a 6 MeV neutron beam. The efficient induction of dicentrics and rings at the irradiation of neutrons compared to those of gamma or X rays especially in a lower dose range, results in a dominant linear component in the linear quadratic model in the dose response relation of a chromosome aberration formation. A marked increase of RBE (relative biological effectiveness) in a lower dose range of neutrons was demonstrated. The radiation doses of the neutron beam as a function of depth, estimated from the yields of dicentrics and rings in a water phantom revealed a fairly good agreement with doses that were physically obtained. The radiation portal margin of the neutron beam was demonstrated to be not as sharp due to a wide penumbra. This wide penumbra and high RBE value, especially at lower dose range of the neutron beam may contribute to the induction of secondary malignancies in the normal tissue surrounding the tumor mass.},
doi = {10.1016/0360-3016(88)90267-2},
url = {https://www.osti.gov/biblio/5200126}, journal = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number = ,
volume = 14:3,
place = {United States},
year = {Tue Mar 01 00:00:00 EST 1988},
month = {Tue Mar 01 00:00:00 EST 1988}
}