Differential penetration of targeting agents into multicellular spheroids derived from human neuroblastoma

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Progress in Clinical and Biological Research; (United States)

OSTI ID:5198006

Mairs, R J; Angerson, W J; Babich, J W; Murray, T ^[1]

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1. Univ. of Glasgow (Scotland)

The authors have used a multicellular tumour spheroid model for determination of the penetration of various targeting agents of potential use in the treatment of neuroblastoma. Both the radiopharmaceutical meta-iodobenzylguanidine (mIBG) and the {beta} subunit of nerve growth factor ({beta}-NGF) distributed uniformly throughout spheroids, though the latter was poorly concentrated relative to mIBG. In contrast, the anti-neuroectodermal monoclonal antibody. UJ13A bound only to peripheral cell layers with little accumulation in the spheroid interior. Differential penetration of targeting agents may influence the choice of conjugated radionuclide which is likely to achieve maximum therapeutic benefit.

• OSTI ID: 5198006
• Journal Information: Progress in Clinical and Biological Research; (United States), Vol. 366; ISSN 0361-7742
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
NEOPLASMS
RADIOIMMUNOTHERAPY
RADIOPHARMACEUTICALS
BIOLOGICAL LOCALIZATION
BIOLOGICAL MODELS
MAN
MONOCLONAL ANTIBODIES
ANIMALS
ANTIBODIES
DISEASES
DRUGS
IMMUNOLOGY
IMMUNOTHERAPY
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
PRIMATES
RADIOIMMUNOLOGY
RADIOLOGY
RADIOTHERAPY
THERAPY
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)