Butylated hydroxyanisole and lung tumor development in A/J mice
A diet containing 0.75% butylated hydroxyanisole (BHA) did not enhance the development of lung tumors in A/J mice if fed for 8 weeks after administration of urethane, benzo(a)pyrene (B(a)P), or dimethylnitrosamine (DMN). Prefeeding animals with BHA partially protected animals against the tumorigenic effect of urethane and B(a)P. Partial protection was also seen in animals given B(a)P and then exposed to BHA in the diet. The two isomers of BHA 3-tert.-butyl-4-hydroxyanisole and 2-tert.-butyl-4-hydroxyanisole) were synthesized and injected ip. They failed to enhance lung tumor development. It is concluded that BHA is not a promoting agent as is butylated hydroxytoluene (BHT) for lung tumors in mice. One possible explanation is that BHA in the diet does not produce the extensive cell proliferation seen in the lungs of mice fed BHT. 19 references, 5 tables.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5193560
- Journal Information:
- Fundam. Appl. Toxicol.; (United States), Vol. 4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTIOXIDANTS
BIOLOGICAL EFFECTS
BENZOPYRENE
CARCINOGENESIS
LUNGS
NEOPLASMS
NITROSAMINES
URETHANE
CELL PROLIFERATION
DIET
EXPERIMENTAL DATA
INTRAPERITONEAL INJECTION
MICE
RESPONSE MODIFYING FACTORS
TUMOR PROMOTERS
AMINES
ANIMALS
AROMATICS
BODY
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CONDENSED AROMATICS
DATA
DISEASES
HYDROCARBONS
INFORMATION
INJECTION
INTAKE
MAMMALS
NITROSO COMPOUNDS
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PROMOTERS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)