Precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons
- Universitaet zu Koeln (West Germany)
- Universitat Heidelberg (West Germany)
- Molecular Therapeutics Inc., West Haven, CT (USA)
Alzheimer's disease (AD) is characterized by the cerebral deposition of fibrillar aggregates of the amyloid A4 protein. Complementary DNA's coding for the precursor of the amyloid A4 protein have been described. In order to identify the structure of the precursor gene relevant clones from several human genomic libraries were isolated. Sequence analysis of the various clones revealed 16 exons to encode the 695 residue precursor protein (PreA4{sub 695}) of Alzheimer's disease amyloid A4 protein. The DNA sequence coding for the amyloid A4 protein is interrupted by an intron. This finding supports the idea that amyloid A4 protein arises by incomplete proteolysis of a larger precursor, and not by aberrant splicing.
- OSTI ID:
- 5190882
- Journal Information:
- Nucleic Acids Research; (UK), Vol. 17:2; ISSN 0305-1048
- Country of Publication:
- United States
- Language:
- English
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RECOMBINANT DNA
DNA SEQUENCING
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PEPTIDE HYDROLASES
AGE GROUPS
AGED ADULTS
BIOLOGY
BODY
CENTRAL NERVOUS SYSTEM
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MOLECULAR STRUCTURE
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550200* - Biochemistry