False-negative dipyridamole-thallium-201 myocardial imaging after caffeine infusion

Journal Article · Thu Aug 01 00:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5189782

Smits, P; Corstens, F H; Aengevaeren, W R; Wackers, F J; Thien, T ^[1]

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1. University Hospital Nijmegen (Netherlands)

The vasodilator effect of intravenously administered dipyridamole may be caused by an increase in endogenous plasma adenosine levels. The authors evaluated the effect of caffeine, an adenosine receptor antagonist, on the diagnostic results of dipyridamole-201Tl myocardial imaging in eight patients with coronary artery disease. Caffeine infusion significantly attenuated the dipyridamole-induced fall in blood pressure and the accompanied increase in heart rate. The infusion of dipyridamole alone resulted in chest pain and ST-segment depressions on the electrocardiogram in four patients, whereas none of these problems occurred when the tests were repeated after caffeine. In six of eight patients, caffeine was responsible for false-negative dipyridamole-201Tl tests. Semiquantitive scores of the dipyridamole-induced 201Tl perfusion defects were decreased by caffeine from 9.0 {plus minus} 0.9 to 2.0 {plus minus} 1.1 points (p less than 0.05). Computerized analysis revealed a caffeine-mediated reduction in the percent reversibility of the images from 46% {plus minus} 16% to 6% {plus minus} 10% (p less than 0.05). They conclude that the use of caffeinated products prior to dipyridamole-201Tl testing may be responsible for false-negative findings.

• OSTI ID: 5189782
• Journal Information: Journal of Nuclear Medicine; (United States), Vol. 32:8; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
HEART
IMAGE PROCESSING
ADENOSINE
BLOOD PRESSURE
CAFFEINE
DATA COVARIANCES
PATIENTS
THALLIUM 201
VASODILATORS
ANALEPTICS
AROMATICS
AZAARENES
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM AGENTS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PROCESSING
PURINES
RADIOISOTOPES
RIBOSIDES
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
XANTHINES
550601* - Medicine- Unsealed Radionuclides in Diagnostics