Intermediates of stigmasterol metabolism in Spodoptera littoralis

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Steroids; (USA)

DOI:https://doi.org/10.1016/0039-128X(89)90018-4· OSTI ID:5186687

Svoboda, J A; Rees, H H; Thompson, M J; Hoggard, N ^[1]

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1. Insect and Nematode Hormone Laboratory, Beltsville, MD (USA)

Stigmasterol-24,28-epoxide, 22E-stigmasta-5,22,24(28E)-trien-3 beta-ol, and 22E-cholesta-5,22,24-trien-3 beta-ol were identified as normal metabolites of (3H)stigmasterol in Spodoptera littoralis larvae. Relative concentrations of all three of these metabolites increased when a diazasterol inhibitor was fed in combination with stigmasterol in the artificial diet. Identification of these sterols as intermediates in the conversion of stigmasterol to cholesterol in this insect indicates that intermediates analogous to fucosterol and fucosterol-24,28-epoxide in the conversion of sitosterol to cholesterol are produced in the metabolism of stigmasterol. This is the first published identification of stigmasterol-24,28-epoxide and 22E-stigmasta-5,22,24(28E)-trien-3 beta-ol as intermediates in this pathway in an insect.

• OSTI ID: 5186687
• Journal Information: Steroids; (USA), Vol. 53:3-5; ISSN 0039-128X
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
STEROLS
METABOLISM
BIOLOGICAL PATHWAYS
INSECTS
LARVAE
MASS SPECTRA
METABOLITES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ANIMALS
ARTHROPODS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INVERTEBRATES
ISOTOPE APPLICATIONS
ORGANIC COMPOUNDS
SPECTRA
STEROIDS
550501* - Metabolism- Tracer Techniques