Effect of polyethylene glycol 400 on the intestinal permeability of carbamazepine in the rabbit

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Pharmaceutical Research; (United States)

DOI:https://doi.org/10.1023/A:1015803312233· OSTI ID:5185953

Riad, L E; Sawchuk, R J ^[1]

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1. College of Pharmacy, Minneapolis, MN (USA)

Because of the limited solubility of carbamazepine, aqueous solutions are usually prepared using glycols as cosolvents. This research focuses on the effect of varying the composition of polyethylene glycol 400 (PEG-400) in aqueous solutions in rabbit intestinal permeability of carbamazepine in the duodenojejunum and the ascending colon using an in situ perfusion technique. In both segments the intestinal permeability varied inversely with the percentage of PEG-400, when the concentration of carbamazepine in the perfusing solution was maintained constant. The decreased permeability may be explained by a reduction in the thermodynamic activity of carbamazepine with increased concentrations of PEG-400, as well as by reverse solvent drag because of the hyperosmolarity of the perfusing solutions.

• OSTI ID: 5185953
• Journal Information: Pharmaceutical Research; (United States), Vol. 8:4; ISSN 0724-8741
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANALGESICS
METABOLISM
INTESTINES
PERMEABILITY
POLYETHYLENE GLYCOLS
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BIOLOGICAL MARKERS
HYPERTONIC SOLUTIONS
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HYDROXY COMPOUNDS
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560300* - Chemicals Metabolism & Toxicology