The role of indium-111 antimyosin (Fab) imaging as a noninvasive surveillance method of human heart transplant rejection

Journal Article · Fri Sep 01 00:00:00 EDT 1989 · Journal of Heart Transplantation; (USA)

OSTI ID:5185814

De Nardo, D; Scibilia, G; Macchiarelli, A G; Cassisi, A; Tonelli, E; Papalia, U; Gallo, P; Antolini, M; Pitucco, G; Reale, A ^[1]

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1. Universita degli Studi di Roma I La Sapienza Policlinico Umberto I (Italy)

The identification of rejection after heart transplantation in patients receiving cyclosporine immunosuppressive therapy requires the endomyocardial biopsy, an invasive method associated with a finite morbidity. To evaluate the role of indium-111 antimyosin (Fab) scintigraphy as a noninvasive surveillance method of heart transplant rejection, the Fab fragment of murine monoclonal antimyosin antibodies labeled with indium-111 was administered intravenously in 30 scintigraphic studies to 10 consecutive heart transplant recipients. Endomyocardial biopsy specimens were obtained 72 hours after each scintigraphic study. Nineteen scintigraphic studies had negative findings; no false negative finding was obtained. Eleven antimyosin scintigraphic studies had positive findings, and in these studies endomyocardial biopsy revealed mild rejection in two cases, moderate acute rejection with myocyte necrosis in two cases, myocyte necrosis as a consequence of ischemic injury in six cases, and possibly cytotoxic damage in one case. Antimyosin scintigraphy may represent a reliable screening method for the surveillance of heart transplant patients. In the presence of a negative finding from antimyosin scintigraphy, it may be possible to avoid endomyocardial biopsy. Conversely, in patients who have a positive finding from antimyosin scintigraphy, the endomyocardial biopsy is mandatory to establish the definitive diagnosis by histologic examination of the myocardium.

• OSTI ID: 5185814
• Journal Information: Journal of Heart Transplantation; (USA), Vol. 8:5; ISSN 0887-2570
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
GRAFT-HOST REACTION
DIAGNOSIS
HEART
TRANSPLANTS
BIOPSY
IMMUNOGLOBULINS
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
INDIUM 111
MONOCLONAL ANTIBODIES
MYOSIN
RADIOIMMUNOSCINTIGRAPHY
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics