Are there ethnic differences in deletions in the dystrophin gene?

Journal Article · Mon Jan 20 00:00:00 EST 1997 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19970120)68:2<152::AID-AJMG6>3.3.CO;2-9· OSTI ID:518287

Banerjee, M; Verma, I C ^[1]

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1. All India Inst. of Medical Sciences, New Delhi (India)

We studied 160 cases of Duchenne muscular dystrophy (DMD) drawn from all parts of India, using multiplex PCR of 27 exons. Of these, 103 (64.4%) showed intragenic deletions. Most (69.7%) of the deletions involved exons 45-51. The phenotype of cases with deletion of single exons did not differ significantly from those with deletion of multiple exons. The distribution of deletions in studies from different countries was variable, but this was accounted for either by the small number of cases studied, or by fewer exons analyzed. It is concluded that there is likely to be no ethnic difference with respect to deletions in the DMD gene. 38 refs., 2 figs., 3 tabs.

• OSTI ID: 518287
• Journal Information: American Journal of Medical Genetics, Vol. 68, Issue 2; Other Information: PBD: 20 Jan 1997
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
GENES
GENE MUTATIONS
SIZE
MUTATION FREQUENCY
DNA SEQUENCING
POLYMERASE CHAIN REACTION
MULTIPLEXERS
MUSCLES
DISEASES
HUMAN POPULATIONS
HEREDITARY DISEASES
PHENOTYPE
DISEASE INCIDENCE
MINORITY GROUPS
INDIA
EXONS