Response to glucose and lipid infusions in sepsis: a kinetic analysis
The kinetics and oxidation of glucose and free fatty acid (FFA) metabolism were assessed in control and Escherichia coli septicemic dogs by using primed, constant infusions of U-/sup 14/C-glucose and 1,2, /sup 13/C-palmitic acid. In the controls, the infusion of glucose suppressed endogenous glucose production completely, whereas, in the septic dogs, only a 30% suppression of glucose production occurred. The ability of the septic dogs to oxidize endogenous or exogenous glucose was decreased significantly. The basal rate of appearance of FFA was significantly higher in the septic dogs, but their ability to oxidize FFA was comparable to that of the control dogs; therefore, the basal rate of FFA oxidation was higher in the septic dogs. These studies indicate that septic dogs have a decreased capacity to oxidize glucose, but that they retain their ability to oxidize long-chain fatty acids. Because the rate of lipolysis was increased in sepsis, lipid was the predominate energy substrate in this septic model.
- Research Organization:
- Univ. of Texas Medical Branch, Galveston
- OSTI ID:
- 5179998
- Journal Information:
- Metab., Clin. Exp.; (United States), Vol. 5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Lipolytic response to glucose infusion in human subjects
Validation of a new method for determination of free fatty acid turnover
Related Subjects
DOGS
BIOCHEMICAL REACTION KINETICS
GLUCOSE
INFUSION
OXIDATION
HEXADECANOIC ACID
CARBON 13
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
ESCHERICHIA COLI
GLUCAGON
INSULIN
KINETICS
METABOLISM
SEPTICEMIA
ALDEHYDES
ANIMALS
BACTERIA
CARBOHYDRATES
CARBON ISOTOPES
CHEMICAL REACTIONS
EVEN-ODD NUCLEI
HEXOSES
HORMONES
INTAKE
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MICROORGANISMS
MONOCARBOXYLIC ACIDS
MONOSACCHARIDES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PEPTIDES
POLYPEPTIDES
PROTEINS
REACTION KINETICS
SACCHARIDES
STABLE ISOTOPES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques