Long-term memory: disruption by inhibitors of protein synthesis and cytoplasmic flow

Journal Article · Thu Jan 01 00:00:00 EST 1981 · Pharmacol., Biochem. Behav.; (United States)

DOI:https://doi.org/10.1016/0091-3057(81)90190-8· OSTI ID:5178199

Flood, J F ^[1]; Landry, D W; Bennett, E L; Jarvik, M E

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1. Univ. of Califorina, Los Angeles

Colchicine (60 ..mu..g/kg), an inhibitor of axoplasmic transport, administered subcutaneously to mice has no detectable effect on retention when given shortly after active avoidance training, nor did a pertaining injection of anisomycin (ANI) have an amnesic effect. However, when ANI was administered shortly prior to training and colchicine was administered after training, retention performance was impaired. The amnesic effect was dependent on the time at which colchicine was administered. The amnesic effect was also obtained when ANI was combined with either vinblastine (6 ..mu..g/kg) or podophyllotoxin (3 ..mu..g/kg), drugs that inhibit axoplasmic transport. Intracerebral injections of colchicine (60 ng to 60 pg) caused amnesia in subjects pretreated with ANI, but not in subjects pretreated with saline. Lumicolchicine, an isomer of colchicine, which has similar central nervous system effects but has a low binding affinity for microtubule protein, did not impair retention in ANI pretreated mice. It is suggested that axonal transport of recently synthesized protein is required for long-term memory storage.

• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 5178199
• Journal Information: Pharmacol., Biochem. Behav.; (United States), Vol. 15:2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
COLCHICINE
BIOLOGICAL EFFECTS
NERVE CELLS
DYNAMIC FUNCTION STUDIES
PROTEINS
INHIBITION
VINBLASTINE
AVOIDANCE
BEHAVIOR
BIOSYNTHESIS
BRAIN
CEREBRUM
MICE
ALKALOIDS
ANIMAL CELLS
ANIMALS
ANTIMITOTIC DRUGS
ANTIPYRETICS
AZOLES
BODY
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
HETEROCYCLIC COMPOUNDS
INDOLES
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRROLES
RODENTS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES
550100* - Behavioral Biology
550200 - Biochemistry