The effect of diet and exercise on incidence of 7,12 dimethylbenz(a)anthracene-induced mammary tumors in virgin BALB/c mice

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5174614

White, M T; Lane, H W; Teer, P; Keith, R E; Strahan, S ^[1]

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1. Auburn Univ., AL (United States) NASA, Houston, TX (United States)

The effects of rotating-drum treadmill exercise and diet on 7,12 dimethylbenz(a)anthracene (DMBA)-induced mammary tumors were investigated in virgin female BALB/c mice. The animals were fed one of three diets: AIN 76 (SD), high-fat diet (HFD), or a restricted calorie diet (RCD). All diets were begun at 6 weeks of age and fed ad libitum except for the restricted diet which was fed at 70% of the SD. At 8 weeks of age all animals received the first of 6 consecutive DMBA doses via gastric tube. Each diet had an exercise and no exercise subgroup. Exercise began at 10 wks of age (6 m/min for 60 min, 5 d/wk) and continued throughout the 9.5 mo. study. Exercise reduced feed consumption in SD and HFD groups. Body weight was similar in all groups with HFDEx having the lowest body wt. Calorie restriction had no effect on body wt. but reduced mammary tumor incidence in the SD groups; however, exercise did affect mammary tumor incidence in the other groups as follows: RCD = 28%, RCDEx = 13%; HFD = 31%, HFDEx = 19%. Caloric consumption appeared to be related to mammary tumor incidence rather than body wt. or dietary fat.

• OSTI ID: 5174614
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZANTHRACENE
CARCINOGENESIS
MAMMARY GLANDS
EXPERIMENTAL NEOPLASMS
DIET
DISEASE INCIDENCE
EXERCISE
MICE
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
GLANDS
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology