Effects of tocopherol and selenium supplementation on vitamin A evaluated by response surface analysis

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5174008

Stoecker, B J; Seaborn, C D; Kiangura, R K; Hermann, J R ^[1]

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1. Oklahoma State Univ., Stillwater (United States)

Sixty-six weanling male rats were fed torula-yeast based diets and deprived of selenium, vitamin A and tocopherol for five weeks. Subsequently a two-factor central composite response surface experimental design was used to determine Se and tocopherol supplementation for nine groups. Selenium, as sodium selenate, was added to the diets at concentrations between 0 and 1.0 ppm. Rats were dosed with 0.2 to 50 mg/day of dl-alpha-tocopherol. All animals were fed 100 ug beta-carotene daily. Body, liver, and spleen weights were not significantly affecteds ofdietary treatments. Dietary Se affected heart weight. Hepatic vitamin A decreased linearly with increasing tocopherol supplements. In the combinations used, tocopherol decreased total vitamin A in liver and kidney but did not interact significantly with Se.

• OSTI ID: 5174008
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SELENIUM
BIOLOGICAL EFFECTS
VITAMIN A
BIOSYNTHESIS
VITAMIN E
DIET
LIVER
RATS
ANIMALS
BODY
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
MAMMALS
ORGANS
RODENTS
SEMIMETALS
SYNTHESIS
VERTEBRATES
VITAMINS
560300* - Chemicals Metabolism & Toxicology