X-ray microscopy studies on the pharmaco-dynamics of therapeutic gallium in rat bones
We describe here our preliminary results on gallium and calcium quantitation and localization using x-ray microscopy techniques at the X-26 beam line of the National Synchrotron Light Source (NSLS) at 50 to 100 ..mu..m resolution and 10/sup )minus/6) gg detection levels. Since the original observation of exogenous gallium accumulation in bones, several studies have demonstrated that gallium nitrate is extremely effective in preserving boen mienral content both in vivo and in vitro. Gallium nitrate therapy normalized serum calcium levels in a study of patients with caner-related hypercalcemia, resistant to standard hydration and diuretic therapy. Recently, gallium nitrate treatment has been shown to halt the accelerated bone resorption that is frequently associated with cancers metastatic to bone. Several lines of evidence from vitro studies recently led to the demonstration of increased bone calcium and improvement in hydroxyapatite crystallinity in adult gallium-treated rats. Evidence is rapidly accumulating that gallium nitrate is an effective, new therapeutic agent for inhibition of accelerated bone resorption associated with cancer-related hypercalcemia. It has also been suggested that gallium could have wide clinical applications in disorders characterized by accelerated calcium loss from bone. 7 refs., 3 figs., 1 tab
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York (USA); Brookhaven National Lab., Upton, NY (USA)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5173347
- Report Number(s):
- BNL-40770; CONF-8708180-7; ON: DE88006298
- Resource Relation:
- Conference: Symposium on X-ray microscopy, Upton, NY, USA, 31 Aug 1987
- Country of Publication:
- United States
- Language:
- English
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46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
BONE TISSUES
SCANNING ELECTRON MICROSCOPY
CALCIUM
GALLIUM
GALLIUM NITRATES
QUANTITATIVE CHEMICAL ANALYSIS
RATS
THERAPY
X-RAY FLUORESCENCE ANALYSIS
ALKALINE EARTH METALS
ANIMAL TISSUES
ANIMALS
BODY
CHEMICAL ANALYSIS
CONNECTIVE TISSUE
ELECTRON MICROSCOPY
ELEMENTS
GALLIUM COMPOUNDS
MAMMALS
METALS
MICROSCOPY
NITRATES
NITROGEN COMPOUNDS
NONDESTRUCTIVE ANALYSIS
OXYGEN COMPOUNDS
RODENTS
TISSUES
VERTEBRATES
X-RAY EMISSION ANALYSIS
550601* - Medicine- Unsealed Radionuclides in Diagnostics
440101 - Radiation Instrumentation- General Detectors or Monitors & Radiometric Instruments