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Title: Influence of thyroid states on stress gastric ulcer formation

Abstract

This study was designed to test the hypothesis that thyroid states may affect the acute development of gastric lesions induced by cold-resistant stress. Normal (euthyroid), hyperthyroid and hypothyroid rats were used. Gastric lesion incidence and severity was significantly increased in hypothyroid rats, whereas in contrast hyperthyroid rats developed significantly less gastric lesions. As anticipated, plasma levels of thyroxin (T/sub 4/) were significantly elevated in hyperthyroid rats, and undetectable in hypothyroid rats. Acute pretreatment with i.p. cimetidine, but not T/sub 4/ 1 h prior to stress completely prevented gastric lesions formation in hypothyroid rats. Finally, binding of /sup 3/H-dihydroalprenolol to ..beta..-adrenergic receptors on brain membranes prepared from frontal cortex was reduced by 20% in hypothyroid rats after 3 h of stress. These and other data contained herein suggest that thyroid hormones contribute to modulate the responsiveness of the gastric mucosa to stress. The increase rate of ulcerogenesis observed in hypothyroid rats appears to be mediated by gastric acid secretion. The central mechanism for this response may involve decreased brain nonadrenergic receptor function.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of Southern California, Los Angeles (USA)
OSTI Identifier:
5169372
Resource Type:
Journal Article
Journal Name:
Life Sci.; (United States)
Additional Journal Information:
Journal Volume: 42:18
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; GASTRIC ACID; SECRETION; GASTROINTESTINAL TRACT; BIOLOGICAL STRESS; ULCERS; THYROID; BIOLOGICAL FUNCTIONS; THYROXINE; BRAIN; CELL MEMBRANES; HYPERTHYROIDISM; HYPOTHYROIDISM; RATS; TRACER TECHNIQUES; TRITIUM COMPOUNDS; AMINO ACIDS; ANIMALS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CELL CONSTITUENTS; CENTRAL NERVOUS SYSTEM; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; FUNCTIONS; GLANDS; HORMONES; ISOTOPE APPLICATIONS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MEMBRANES; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; RODENTS; THYROID HORMONES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Hernandez, D E, Walker, C H, and Mason, G A. Influence of thyroid states on stress gastric ulcer formation. United States: N. p., 1988. Web. doi:10.1016/0024-3205(88)90042-2.
Hernandez, D E, Walker, C H, & Mason, G A. Influence of thyroid states on stress gastric ulcer formation. United States. https://doi.org/10.1016/0024-3205(88)90042-2
Hernandez, D E, Walker, C H, and Mason, G A. 1988. "Influence of thyroid states on stress gastric ulcer formation". United States. https://doi.org/10.1016/0024-3205(88)90042-2.
@article{osti_5169372,
title = {Influence of thyroid states on stress gastric ulcer formation},
author = {Hernandez, D E and Walker, C H and Mason, G A},
abstractNote = {This study was designed to test the hypothesis that thyroid states may affect the acute development of gastric lesions induced by cold-resistant stress. Normal (euthyroid), hyperthyroid and hypothyroid rats were used. Gastric lesion incidence and severity was significantly increased in hypothyroid rats, whereas in contrast hyperthyroid rats developed significantly less gastric lesions. As anticipated, plasma levels of thyroxin (T/sub 4/) were significantly elevated in hyperthyroid rats, and undetectable in hypothyroid rats. Acute pretreatment with i.p. cimetidine, but not T/sub 4/ 1 h prior to stress completely prevented gastric lesions formation in hypothyroid rats. Finally, binding of /sup 3/H-dihydroalprenolol to ..beta..-adrenergic receptors on brain membranes prepared from frontal cortex was reduced by 20% in hypothyroid rats after 3 h of stress. These and other data contained herein suggest that thyroid hormones contribute to modulate the responsiveness of the gastric mucosa to stress. The increase rate of ulcerogenesis observed in hypothyroid rats appears to be mediated by gastric acid secretion. The central mechanism for this response may involve decreased brain nonadrenergic receptor function.},
doi = {10.1016/0024-3205(88)90042-2},
url = {https://www.osti.gov/biblio/5169372}, journal = {Life Sci.; (United States)},
number = ,
volume = 42:18,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1988},
month = {Fri Jan 01 00:00:00 EST 1988}
}