Clinical and immunological studies of cadaveric renal transplant recipients given total-lymphoid irradiation and maintained on low-dose prednisone

Journal Article · Tue Mar 01 00:00:00 EST 1988 · Transplantation; (United States)

DOI:https://doi.org/10.1097/00007890-198803000-00008· OSTI ID:5168157

Saper, V; Chow, D; Engleman, E D; Hoppe, R T; Levin, B; Collins, G; Strober, S

Twenty-five recipients of cadaveric renal transplants were given total lymphoid irradiation (TLI), perioperative antithymocyte globulin, and low-dose prednisone as the sole maintenance immunosuppressive drug. Nine patients were diabetic, and follow-up was between 19 and 37 months. One-year graft and patient survival was 76% and 87%, respectively, Serious complications included four deaths from cardiovascular disorders, and two deaths from viral infections. Studies of peripheral blood T cell subsets showed a prolonged reduction in the absolute number of helper (Leu-3+) cells, and a rapid recovery of cytotoxic/suppressor (Leu-2+) cells. Analysis of the latter subset, using the monoclonal antibody 9.3, showed that the ratio of suppressor/cytotoxic cells was approximately 10:1. The normal ratio is 1:1. The mean mixed leukocyte reaction remained below 30% of the pre-TLI value for 6 months, and approached 80% at two years. Similar kinetics were observed in the proliferative response to mitogens. The results show that maintenance immunosuppressive drug therapy can be reduced after TLI as compared with conventional drug regimens that use prednisone in combination with cyclosporine and/or azathioprine.

• Research Organization: Stanford Univ. School of Medicine, CA (USA)
• OSTI ID: 5168157
• Journal Information: Transplantation; (United States), Vol. 45:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
KIDNEYS
TRANSPLANTS
LYMPHATIC SYSTEM
IRRADIATION
LYMPHOCYTES
CELL PROLIFERATION
BIOLOGICAL RADIATION EFFECTS
DIABETES MELLITUS
DOSE-RESPONSE RELATIONSHIPS
GLOBULINS
IMMUNOSUPPRESSION
MITOGENS
MONOCLONAL ANTIBODIES
PATIENTS
PREDNISONE
ADRENAL HORMONES
ANIMAL CELLS
ANTIBODIES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
DISEASES
ENDOCRINE DISEASES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
LEUKOCYTES
MATERIALS
METABOLIC DISEASES
ORGANIC COMPOUNDS
ORGANS
PREGNANES
PROTEINS
RADIATION EFFECTS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
560151* - Radiation Effects on Animals- Man