Effect of nickel and cadmium chloride on autonomic and behavioral thermoregulation in mice
Male BALB/c mice were injected intraperitoneally (i.p.) with nickel chloride (0, 5, 10, and 15 mg/kg) or cadmium chloride (0, 2, 4, and 6 mg/kg) while preferred ambient temperature (Ta) and activity were measured. Both metals caused drastic reductions in preferred Ta and activity within 30-min postinjection. Preferred Ta and activity were depressed for up to 90 min following nickel and cadmium injection. In a second experiment, body temperature was measured 60 min following the injection of nickel or cadmium chloride at a Ta of 20, 30, or 35 C. Nickel and cadmium caused a drastic reduction in body temperature when injected at a Ta of 20 and 30 C but produced either no effect or only a slight elevation in body temperature at a Ta of 35 C. In a third experiment, metabolic rate was measured continuously for 60 min following the i.p. injection of a relatively large dose of nickel (15 mg/kg) or cadmium chloride (6 mg/kg) at a Ta of 20, 30, and 35 C. Both metals caused significant reductions in metabolic rate at Ta's of 20 and 30 C.
- Research Organization:
- Environmental Protection Agency, Research Triangle Park, NC (USA). Health Effects Research Lab.
- OSTI ID:
- 5166358
- Report Number(s):
- PB-88-171103/XAB; EPA-600/J-86/449
- Resource Relation:
- Other Information: Pub. in Neurotoxicology-7, No. 3, 97-106(1986)
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CADMIUM CHLORIDES
BIOLOGICAL EFFECTS
MICE
THERMOREGULATION
NICKEL CHLORIDES
BODY TEMPERATURE
LABORATORY ANIMALS
METABOLISM
TOXICITY
ANIMALS
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
CONTROL
HALIDES
HALOGEN COMPOUNDS
MAMMALS
NICKEL COMPOUNDS
RODENTS
TEMPERATURE CONTROL
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology