Biologic interactions between smoking and occupational exposures
Cigarette smoking is a major cause of cancer and lung disease in the U.S. population. The biological processes that underlie the response of the lung to cigarette smoke are important considerations for designing analyses of the effects of occupational exposures. Interactions between cigarette smoking and occupational exposures may occur through a combined effect on the mechanism of disease production, through an effect on the dose of the toxic substances that reach the target issue, or through an effect on the response of the lung to the toxic agents. Disease due to occupational exposures can occur in a similar pattern in both smokers and nonsmokers; however, as more complex interactions are examined, different responses to the same occupational exposure may be identified for smokers and nonsmokers. It is only through the successful intermingling of biologic information with epidemiologic data that these interactions can be fully examined. 66 references.
- OSTI ID:
- 5164904
- Journal Information:
- Am. J. Ind. Med.; (United States), Vol. 13:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
LUNGS
NEOPLASMS
RESPIRATORY SYSTEM DISEASES
EPIDEMIOLOGY
TOBACCO SMOKES
TOXICITY
XENOBIOTICS
OCCUPATIONAL EXPOSURE
OCCUPATIONAL DISEASES
REVIEWS
SYNERGISM
AEROSOLS
BODY
COLLOIDS
DISEASES
DISPERSIONS
DOCUMENT TYPES
ORGANS
RESIDUES
RESPIRATORY SYSTEM
SMOKES
SOLS
560300* - Chemicals Metabolism & Toxicology
550900 - Pathology