Xenon-133 hepatic retention ratio: A useful index for fatty liver quantification

Journal Article · Sun Oct 01 00:00:00 EDT 1989 · Journal of Nuclear Medicine; (USA)

OSTI ID:5158925

Yeh, S H; Wu, L C; Wang, S J; Lin, H C; Liu, R S; Lee, S D; Wu, J C ^[1]

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1. Veterans General Hospital, Taipei (Taiwan)

Xenon-133 hepatic retention ratio was developed for quantifying fatty liver. Data were acquired in frame mode in the hepatic region and both lung bases for 5 min after rebreathing 20 mCi of gaseous {sup 133}Xe and for another 5 min during washout. Static ({sup 99m}Tc)sulfur colloid liver imaging was performed with the patient in the identical position immediately after the ventilation study and data were stored for liver localization. A hepatic time-activity curve corrected for background activity was generated. The 133Xe retention ratio was derived by dividing the activity at 3.5 min after washout by the peak activity. The data of 16 controls and 20 patients with fatty liver were analyzed. The retention ratio (mean +/- s.d.) was greatly increased in patients with fatty infiltration (0.43 +/- 0.20 vs. 0.04 +/- 0.08 in controls, p less than 0.001). There was a strong positive correlation between the {sup 133}Xe retention ratios and percentage of fat on biopsy as assessed by the amount of the liver tissue occupied by fat globules on H E stained sections. The {sup 133}Xe hepatic retention ratio is a simple, accurate and clinically useful index of detecting, quantifying and managing fatty infiltration of the liver.

• OSTI ID: 5158925
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 30:10; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIGESTIVE SYSTEM DISEASES
DIAGNOSIS
LIVER
EMISSION COMPUTED TOMOGRAPHY
COLLOIDS
ISOMERIC NUCLEI
PATIENTS
SULFUR
TECHNETIUM 99
TRACER TECHNIQUES
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISPERSIONS
ELEMENTS
EVEN-ODD NUCLEI
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
TOMOGRAPHY
XENON ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics