The palliation of osseous metastasis with sup 32 P or sup 89 Sr compared with external beam and hemibody irradiation: A historical perspective

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Cancer Investigation; (USA)

DOI:https://doi.org/10.3109/07357908909038281· OSTI ID:5157165

Montebello, J F; Hartson-Eaton, M ^[1]

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1. Indiana Univ. School of Medicine, Indianapolis (USA)

Radiation is an effective modality for palliation of osseous metastases. In patients with a limited number of lesions, local external beam irradiation is the most expedient method of delivering radiation therapy. Complete or partial relief of pain will occur in 80-90% of patients. When metastases are widespread or when new sites continue to appear, localized external irradiation becomes logistically difficult. In such cases, hemibody irradiation has been effective with an overall response rate of 85%. However, nausea, vomiting, diarrhea, and bone marrow and pulmonary toxicity may complicate therapy. In these cases, an effective alternative is systemic phosphorus-32 ({sup 32}P) or strontium-89 ({sup 89}Sr). Relief of pain in the range of 60-90% has been reported. Toxicity of {sup 32}P is largely that of bone marrow suppression, while {sup 89}Sr appears to be relatively marrow-sparing. In this review, we consider systemic {sup 32}P or {sup 89}Sr as viable options to external beam or hemibody irradiation in the presence of numerous bone metastases. 105 references.

• OSTI ID: 5157165
• Journal Information: Cancer Investigation; (USA), Vol. 7:2; ISSN 0735-7907
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
METASTASES
RADIOTHERAPY
COMPARATIVE EVALUATIONS
SKELETON
PHOSPHORUS 32
RADIATION DOSES
REVIEWS
SIDE EFFECTS
STRONTIUM 89
ALKALINE EARTH ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DOCUMENT TYPES
DOSES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
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LIGHT NUCLEI
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PHOSPHORUS ISOTOPES
RADIOISOTOPES
RADIOLOGY
STRONTIUM ISOTOPES
THERAPY
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