Abnormal ventilation scans in middle-aged smokers. Comparison with tests of overall lung function
Abstract
The uniformity of regional ventilation during tidal breathing has been assessed using continuous inhalation of krypton-81m in 43 male, lifelong nonsmokers and 46 male, current cigarette smokers (mean daily consumption 24.1 cigarettes/day) between 44 and 61 yr of age and with mild or no respiratory symptoms. All subjects had normal chest radiographs. The results of the ventilation scans were compared with tests of overall lung function (spirometry, maximal expiratory flow-volume curves, and single-breath N2 test). Diffuse abnormalities of the ventilation scan were found in 19 (41%) of the 46 smokers but in none of the nonsmokers. Focal abnormalities were found in 7 smokers and 3 nonsmokers. Smokers showed the expected abnormalities in overall lung function (reduced FEV1 and VC, increased single-breath N2 slope, and closing volume), but in individual smokers there was only a weak relation between the severity of abnormality of overall lung function and an abnormal ventilation scan. Abnormal scans could be found when overall lung function was normal and were not invariably found when significant abnormalities in FEV1/VC or N2 slope were present. There was no relation between the presence of chronic expectoration and an abnormal scan. The prognostic significance of an abnormal ventilation scan in suchmore »
- Authors:
- Publication Date:
- Research Org.:
- Royal Postgraduate Medical School, London, England
- OSTI Identifier:
- 5150537
- Resource Type:
- Journal Article
- Journal Name:
- Am. Rev. Respir. Dis.; (United States)
- Additional Journal Information:
- Journal Volume: 1
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHEST; RADIOISOTOPE SCANNING; LUNGS; DYNAMIC FUNCTION STUDIES; TOBACCO SMOKES; BIOLOGICAL EFFECTS; COMPARATIVE EVALUATIONS; INHALATION; ISOMERIC NUCLEI; KRYPTON 81; RESPIRATION; SYMPTOMS; AEROSOLS; BETA DECAY RADIOISOTOPES; BODY; BODY AREAS; COLLOIDS; COUNTING TECHNIQUES; DISPERSIONS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KRYPTON ISOTOPES; NUCLEI; ORGANS; RADIOISOTOPES; RESIDUES; RESPIRATORY SYSTEM; SECONDS LIVING RADIOISOTOPES; SMOKES; SOLS; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics; 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
Citation Formats
Barter, S J, Cunningham, D A, Lavender, J P, Gibellino, F, Connellan, S J, and Pride, N B. Abnormal ventilation scans in middle-aged smokers. Comparison with tests of overall lung function. United States: N. p., 1985.
Web.
Barter, S J, Cunningham, D A, Lavender, J P, Gibellino, F, Connellan, S J, & Pride, N B. Abnormal ventilation scans in middle-aged smokers. Comparison with tests of overall lung function. United States.
Barter, S J, Cunningham, D A, Lavender, J P, Gibellino, F, Connellan, S J, and Pride, N B. 1985.
"Abnormal ventilation scans in middle-aged smokers. Comparison with tests of overall lung function". United States.
@article{osti_5150537,
title = {Abnormal ventilation scans in middle-aged smokers. Comparison with tests of overall lung function},
author = {Barter, S J and Cunningham, D A and Lavender, J P and Gibellino, F and Connellan, S J and Pride, N B},
abstractNote = {The uniformity of regional ventilation during tidal breathing has been assessed using continuous inhalation of krypton-81m in 43 male, lifelong nonsmokers and 46 male, current cigarette smokers (mean daily consumption 24.1 cigarettes/day) between 44 and 61 yr of age and with mild or no respiratory symptoms. All subjects had normal chest radiographs. The results of the ventilation scans were compared with tests of overall lung function (spirometry, maximal expiratory flow-volume curves, and single-breath N2 test). Diffuse abnormalities of the ventilation scan were found in 19 (41%) of the 46 smokers but in none of the nonsmokers. Focal abnormalities were found in 7 smokers and 3 nonsmokers. Smokers showed the expected abnormalities in overall lung function (reduced FEV1 and VC, increased single-breath N2 slope, and closing volume), but in individual smokers there was only a weak relation between the severity of abnormality of overall lung function and an abnormal ventilation scan. Abnormal scans could be found when overall lung function was normal and were not invariably found when significant abnormalities in FEV1/VC or N2 slope were present. There was no relation between the presence of chronic expectoration and an abnormal scan. The prognostic significance of an abnormal ventilation scan in such smokers remains to be established.},
doi = {},
url = {https://www.osti.gov/biblio/5150537},
journal = {Am. Rev. Respir. Dis.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {Mon Jul 01 00:00:00 EDT 1985},
month = {Mon Jul 01 00:00:00 EDT 1985}
}