Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition

Journal Article · Thu Aug 01 00:00:00 EDT 1985 · Gastroenterology; (United States)

OSTI ID:5149280

Mojaverian, P; Ferguson, R K; Vlasses, P H; Rocci, Jr, M L; Oren, A; Fix, J A; Caldwell, L J; Gardner, C

In animal and human studies, the gastric emptying of large (greater than 1 mm) indigestible solids is due to the activity of the interdigestive migrating myoelectric complex. The gastric residence time (GRT) of an orally administered, nondigestible, pH-sensitive, radiotelemetric device (Heidelberg capsule) was evaluated in three studies in healthy volunteers. In 6 subjects, the GRT of the Heidelberg capsule was compared with the half-emptying time (t1/2) of diethylenetriaminepentaacetic acid labeled with technetium 99m after a 4-ml/kg liquid fatty meal. The mean (+/-SD) GRT (4.3 +/- 1.4 h) was significantly (p less than 0.001) longer than the mean t1/2 (1.1 +/- 0.3 h); the GRT was prolonged compared with the t1/2 in each subject. In a randomized, crossover trial in 10 subjects, frequent feeding caused a dramatic prolongation in mean GRT of the capsule compared with the fasting state (greater than 14.5 vs. 0.5 h, p less than 0.005). In another crossover study in 6 subjects, the GRT of the capsule was evaluated after an overnight fast, a standard breakfast including solid food, and a liquid meal (i.e., 200 ml of diluted light cream). The mean GRT was 2.6 +/- 0.9 h after the liquid meal vs. 1.2 +/- 0.8 h after fasting (p less than 0.025). The mean GRT after the breakfast was 4.8 +/- 1.5 h, which was significantly greater than that after fasting (p less than 0.001) and after the liquid meal (p less than 0.01). These data suggest that the GRT of the Heidelberg capsule is a marker of the interdigestive migrating myoelectric complex in humans, the interdigestive migrating myoelectric complex can be markedly delayed by frequent feedings with solids, and the interdigestive migrating myoelectric complex is delayed by both liquid and solid meals.

• Research Organization: Jefferson Medical College of Thomas Jefferson Univ., Philadelphia, PA
• OSTI ID: 5149280
• Journal Information: Gastroenterology; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CAPSULES
DIGESTION
DIGESTIVE SYSTEM
DYNAMIC FUNCTION STUDIES
FOOD
BIOLOGICAL MARKERS
DTPA
ELECTROPHYSIOLOGY
FASTING
GASTRIC ACID
ISOMERIC NUCLEI
TECHNETIUM 99
TELEMETRY
TRACER TECHNIQUES
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
COMMUNICATIONS
CONTAINERS
DATA TRANSMISSION
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PHYSIOLOGY
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
TECHNETIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques