Model studies in cytochrome P-450 mediated toxicity of halogenated compounds: radical processes involving iron porphyrins
Haloalkane toxicity originates from attack on biological targets by reactive intermediates derived from haloalkane metabolism by a hemoprotein, cytochrome P-450. Carbon-centered radicals and their peroxylderivatives are most likely involved. The reactions of iron porphyrin - a model for cytochrome P-450 - with various carbon-centered and peroxyl radicals generated by pulse radiolysis are examined. Competition between iron porphyrin and unsaturated fatty acids for attack by peroxyl radicals is pointed out. These kinetic data are used to derive a model for toxicity of haloalkanes with particular attention to carbon tetrachloride and halothane. The importance of local oxygen concentration and structural arrangement of fatty acids around cytochrome P-450 is emphasized. 56 references.
- Research Organization:
- Museum National d'Histoire Naturelle, Paris, France
- OSTI ID:
- 5148540
- Journal Information:
- Environ. Health Perspect.; (United States), Vol. 64
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CYTOCHROMES
BIOCHEMICAL REACTION KINETICS
HALOGENATED ALIPHATIC HYDROCARBONS
TOXICITY
PEROXY RADICALS
CARBON TETRACHLORIDE
CARBOXYLIC ACIDS
IRON
METABOLISM
METABOLITES
PORPHYRINS
RADIOLYSIS
REACTION INTERMEDIATES
STRUCTURE-ACTIVITY RELATIONSHIPS
CHEMICAL RADIATION EFFECTS
CHEMICAL REACTIONS
CHEMISTRY
CHLORINATED ALIPHATIC HYDROCARBONS
DECOMPOSITION
ELEMENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
KINETICS
METALS
ORGANIC ACIDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PROTEINS
RADIATION CHEMISTRY
RADIATION EFFECTS
RADICALS
REACTION KINETICS
TRANSITION ELEMENTS
560301* - Chemicals Metabolism & Toxicology- Cells- (-1987)