Cytoplasmic superoxide dismutase and catalase activity and resistance to radiation lethality in murine tumor cells

Conference · Thu May 01 00:00:00 EDT 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5148505

Davy, C A; Tesfay, Z; Jones, J; Rosenberg, R C; McCarthy, C; Rosenberg, S O

Reduced species of molecular oxygen are produced by the interaction of ionizing radiation with aqueous solutions containing molecular oxygen. The enzymes catalase and superoxide dismutase (SOD) are thought to function in vivo as scavengers of metabolically produced peroxide and superoxide respectively. SOD has been shown to protect against the lethal effects of ionizing radiation in vitro and in vivo. The authors have investigated the relationship between the cytosolic SOD catalase content and the sensitivity to radiation lethality of a number of murine cell lines (402AX, EL-4, MB-2T3, MB-4, MEL, P-815, SAI, SP-2, and SV-3T3). K/sub i/(CN/sup -/) for murine Cu-Zn-SOD was determined to be 6.8 x 10/sup -6/ M. No cytosolic Mn-SOD activity was found in any of the cell lines studied. No correlation was found between the cytosolic Cu-Zn-SOD or cytosolic catalase activity and the resistance to radiation lethality or the murine cell lines studied.

• Research Organization: Howard Univ., Washington, DC
• OSTI ID: 5148505
• Report Number(s): CONF-8606151-
• Journal Information: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Vol. 45:6; Conference: 76. annual meeting of the Federation of American Society for Experimental Biology, Washington, DC, USA, 8 Jun 1986
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AZIDES
BIOLOGICAL EFFECTS
HYDROGEN PEROXIDE
SUPEROXIDE DISMUTASE
ENZYME ACTIVITY
BACTERIA
BIOCHEMICAL REACTION KINETICS
HYDROXYL RADICALS
IRON
REDOX POTENTIAL
ELEMENTS
ENZYMES
HYDROGEN COMPOUNDS
KINETICS
METALS
MICROORGANISMS
NITROGEN COMPOUNDS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEROXIDES
RADICALS
REACTION KINETICS
TRANSITION ELEMENTS
560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987)