Influence of selenium, age and dosage of 7,12-dimethylbenz(a)anthracene (DMBA) on the in vivo formation of DNA adducts in mammary tissue

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5146452

Liu, Jinzhou; Milner, J A ^[1]

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1. Pennsylvania State Univ., University Park (United States)

Diets formulated to contain selenium, as sodium selenite, 0.1 or 2 {mu}g/g were fed for 2 weeks prior to DMBA treatment. Food intake and weight gain were not influenced by Se intake. Anti- and syn-dihydrodiol epoxide adducts reached maximum binding by 24 h. Se supplementation inhibited by about 50% the appearance of both anti-and syn- DMBA-DNA adducts. Dietary selenium increased the rate of removal of the anti-dihydrodiol epoxide adduct bound to guanine, but delayed the removal of the other adducts. The occurrence of DMBA-DNA adducts correlated positively with the dosage of DMBA administered. Binding increased about 40% as the rat's age increased from 36 to 125 d. Se supplementation inhibited binding in 36, 54 and 125 d old rats. These data confirmed that dietary selenium is effective in inhibiting in vivo metabolism of DMBA.

• OSTI ID: 5146452
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZANTHRACENE
METABOLISM
DNA ADDUCTS
BIOSYNTHESIS
MAMMARY GLANDS
EXPERIMENTAL NEOPLASMS
SELENIUM
BIOLOGICAL EFFECTS
AGE DEPENDENCE
CARCINOGENESIS
IN VIVO
INHIBITION
RATS
ADDUCTS
ANIMALS
AROMATICS
BODY
CONDENSED AROMATICS
ELEMENTS
GLANDS
HYDROCARBONS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RODENTS
SEMIMETALS
SYNTHESIS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology