A method for evaluating the toxicity of industrial solvent mixtures
- General Motors Research and Development Center, Warren, MI (United States). Automotive Safety and Health Research Dept.
The toxicity of a mixture of toluene and mixed xylenes was studied with the frog embryo teratogenesis assay-Xenopus (FETAX). Single compound experiments with either toluene or mixed xylenes show that growth inhibition, not mortality or malformation, is the most sensitive toxic endpoint in the FETAX system (i.e., growth is inhibited at lower exposure concentrations than those resulting in malformations and mortality). A multiple logistic regression analysis model described mortality and malformation as functions of exposure concentrations of toluene and mixed xylenes. The results indicate that toluene and mixed xylenes are additive in their effects on mortality in the FETAX system. Further experimentation is necessary to validate the model`s ability to describe malformation as a function of coexposure to toluene and mixed xylenes.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 514536
- Journal Information:
- Environmental Toxicology and Chemistry, Vol. 16, Issue 5; Other Information: PBD: May 1997
- Country of Publication:
- United States
- Language:
- English
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