Effect of subacute exposure to NO/sub 2/ on lymphocytes required for antibody responses

Journal Article · Wed Dec 01 00:00:00 EST 1982 · Environ. Res.; (United States)

OSTI ID:5144608

Fujimaki, H; Shimizu, F; Kubota, K

BALB/c mice were continuously exposed to 0.4 and 1.6 ppm NO/sub 2/ for 4 weeks and the effects on lymphocytes which are required for primary and secondary antibody responses to sheep red blood cells were examined in vitro. The primary antibody response was significantly suppressed by both concentrations of NO/sub 2/, whereas the secondary antibody response was slightly stimulated by 1.6 ppm NO/sub 2/ exposure. In reconstitution experiments no significant differences were observed in the activities of T and B lymphocytes from mice exposed to 1.6 ppm NO/sub 2/.

• Research Organization: National Inst. for Environmental Studies, Yatabe-machi Tsukuba Ibaraki, Japan
• OSTI ID: 5144608
• Journal Information: Environ. Res.; (United States), Vol. 29:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NITROGEN DIOXIDE
BIOLOGICAL EFFECTS
ANTIBODY FORMATION
CHRONIC EXPOSURE
IN VITRO
LYMPHOCYTES
MICE
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHALCOGENIDES
CONNECTIVE TISSUE CELLS
LEUKOCYTES
MAMMALS
MATERIALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
OXIDES
OXYGEN COMPOUNDS
RODENTS
SOMATIC CELLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)