Effects of brief hypoxia and hyperoxia on tissue element levels in the development chick embryo
- Dept. of Agriculture, Beltsville, MD (United States) Oregon Health Sciences Univ., Portland (United States)
Brief hypoxia or hyperoxia has been shown to affect growth and metabolism of chick embryos during the later stages of development. The objective of this experiment was to alter the availability of oxygen to chick embryos developing in ovo and to determine the effects on tissue levels of Zn, Cu, Fe and Mn. Hypoxia reduced embryo, heart, brain and liver wts (wet wt), whereas, hyperoxia increased embryo, heart, lung and liver wts compared to normoxic controls. Chorioallantoic membrane (CAM) wt was increased by hypoxia and reduced by hyperoxia. Livers from hyperoxic embryos contained more Zn, Fe and Mn and less Cu than livers from hypoxic or normoxic embryos. Tissue levels of Zn, Cu, Fe and Mn were reduced in brains from hypoxic compared to hyperoxic or normoxic embryos. Hyperoxia increased the concentrations of Zn and Cu in CAM; whereas, hypoxia reduced the levels of Zn and Fe. The amounts of Zn and Cu were increased in hyperoxic compared to normoxic lungs. Hearts from hyperoxic embryos had more Zn, Cu and Mn than hypoxic or normoxic hearts. Hypoxic yolk sac contained more Zn, Cu and Mn than hyperoxic or normoxic yolk sac. Except for yolk sac, the amounts of Zn, Cu, Fe and Mn in tissues from normoxic embryos increased from day 15 to day 18 of incubation in concert with tissue growth. The authors conclude that the availability of O{sub 2} to the developing chick embryo affects tissue trace element levels either through its effects on tissue growth or via effects on the regulation of trace element uptake and assimilation by the tissues.
- OSTI ID:
- 5144523
- Report Number(s):
- CONF-9104107-; CODEN: FAJOE
- Journal Information:
- FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
- Country of Publication:
- United States
- Language:
- English
Similar Records
Influence of manganese on the distribution of essential trace elements. II. The tissue distribution of manganese, magnesium, zinc, iron, and copper in rats after chronic manganese exposure
Magnetic resonance imaging (MRI) investigation of the effect of dietary Zn or Cu deficiency and hyperoxia on the oxygen free radical defense system in rats
Related Subjects
ANOXIA
BIOLOGICAL EFFECTS
COPPER
METABOLISM
IRON
MANGANESE
ZINC
ANIMAL GROWTH
CHICKENS
EMBRYOS
TISSUE DISTRIBUTION
TRACE AMOUNTS
ANIMALS
BIRDS
DISTRIBUTION
ELEMENTS
FOWL
GROWTH
METALS
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology