High mortality rates occur in copper deficient rats exposed to a normally nonlethal endotoxin treatment

Conference · Fri Mar 15 00:00:00 EST 1991 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:5143910

DiSilvestro, R; Joseph, E; Yang, F L ^[1]

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1. Ohio State Univ., Columbus (United States)

Endotoxin hepatotoxicity is proposed to occur by processes which could be retarded by 3 copper enzymes: ceruloplasmin, Cu-Zn superoxide dismutase (SOD), and extracellular (EC) SOD. Weanling rats fed low copper for 40 days showed low activity levels of these enzymes, and a very high mortality rate 20 h after endotoxin injection. No rats fed adequate copper died from this treatment. In addition, serum transaminase activities, indicators of liver damage, were elevated by 3 h to a greater extent in the deficient rats than in the adequates. The high susceptibility to endotoxemia in the deficient rats was not associated with low hepatic glutathione, high liver malondialedhyde, nor restricted metallothionein induction 3 h after endotoxin injection. Endotoxin reduced serum EC SOD activities in adequate and deficient rats, but final values were lower in the latter. Studies on roles of specific copper enzymes in resistance to endotoxemia are currently underway.

• OSTI ID: 5143910
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 5:5; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CERULOPLASMIN
BIOSYNTHESIS
COPPER
BIOLOGICAL EFFECTS
METABOLIC DISEASES
PATHOGENESIS
SUPEROXIDE DISMUTASE
AMINOTRANSFERASES
ENDOTOXINS
ENZYME ACTIVITY
LIVER
METABOLISM
MORTALITY
NUTRITIONAL DEFICIENCY
RATS
ANIMALS
ANTIGENS
BODY
COMPLEXES
COPPER COMPLEXES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
ENZYMES
GLANDS
GLOBULINS
GLOBULINS-ALPHA
HAZARDOUS MATERIALS
MAMMALS
MATERIALS
METALLOPROTEINS
METALS
NITROGEN TRANSFERASES
ORGANIC COMPOUNDS
ORGANS
OXIDOREDUCTASES
PROTEINS
RODENTS
SYNTHESIS
TOXIC MATERIALS
TOXINS
TRANSFERASES
TRANSITION ELEMENT COMPLEXES
TRANSITION ELEMENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology