Effect of antisecretory agents and vagotomy on healing of chronic cysteamine-induced duodenal ulcers in rats
Penetrated cysteamine-induced duodenal ulcers in rats have a very prolonged course of healing. In this study, it was investigated how much the healing of these ulcers is accelerated by some treatments. The treatments included omeprazole, cimetidine, and truncal vagotomy. In addition, the effect of omeprazole and cimetidine on gastric acid secretion was investigated in chronic gastric fistula rats. After 25 days of treatment, significantly more rats in the treated groups had healed ulcers than in the control group. There was little further improvement up to 100 days of treatment, and the difference between treated and untreated groups decreased. The morphology of healing ulcers in treated and untreated rats was also compared. In controls, there was a simultaneous regeneration of mucosa and the submucosal Brunner's glands from the edges of the ulcer, the slow proliferation rate of the latter probably being decisive for the prolonged healing. In the treated rats, the mucosa first regenerated with formation of crypts and low villi and subsequently, the Brunner's glands were formed by proliferation from the bottom of the crypts.
- OSTI ID:
- 5143793
- Journal Information:
- Dig. Dis. Sci.; (United States), Vol. 7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
MEA
TOXICITY
BENZIMIDAZOLES
DRUGS
GASTRIC ACID
HEALING
RATS
SMALL INTESTINE
SURGERY
THERAPY
ULCERS
VAGUS
AMINES
ANIMALS
AUTONOMIC NERVOUS SYSTEM
AZOLES
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BODY
BODY FLUIDS
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
INTESTINES
MAMMALS
MATERIALS
MEDICINE
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIOPROTECTIVE SUBSTANCES
RECOVERY
RODENTS
THIOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)