Depuration rates of chlordane compounds from rat fat
- Indiana Univ., Bloomington (United States)
Rats were fed a diet containing 10 ppm of technical chlordane for 28 days. The depuration of the various chlordane compounds was then followed for 32 days. The concentrations of 14 components or metabolites of technical chlordane were measured in the adipose tissues of 21 rats, using electron capture, negative ionization mass spectrometry, coupled with capillary gas chromatography. The half-lives of the two major octachloro isomers, {gamma}-and {alpha}-chlordane, were determined to be 7.1 and 5.9 days, respectively. The half-lives of the nonachlors were 9.7 (cis-nonachlor), 14.3 (trans-nonachlor), and 54.1 days (nonachlor III). The depuration rates seem to be controlled by three structural features of the molecules: the total number and configuration of the chlorines on ring 1 and the number of chlorines on carbon 2.
- OSTI ID:
- 5138985
- Journal Information:
- Environmental Science and Technology; (United States), Vol. 25:6; ISSN 0013-936X
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
PESTICIDES
CLEARANCE
ADIPOSE TISSUE
BIOCHEMICAL REACTION KINETICS
CHLORINATED AROMATIC HYDROCARBONS
GAS CHROMATOGRAPHY
GEL PERMEATION CHROMATOGRAPHY
HALF-LIFE
ISOMERS
LIQUID COLUMN CHROMATOGRAPHY
MASS SPECTROSCOPY
METABOLISM
METABOLITES
MOLECULAR STRUCTURE
RATS
ANIMAL TISSUES
ANIMALS
AROMATICS
BODY
CHROMATOGRAPHY
CONNECTIVE TISSUE
DAYS LIVING RADIOISOTOPES
HALOGENATED AROMATIC HYDROCARBONS
ISOTOPES
KINETICS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
RODENTS
SEPARATION PROCESSES
SPECTROSCOPY
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology