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Title: Effects of experimental varicocele require neither adrenal contribution nor venous reflux

Abstract

Experimental left varicocele (ELV) is known to induce bilateral changes in the rat testis that, where comparisons are possible, are similar to the changes induced by unilateral varicocele in the human. In the present study, we have determined whether or not left adrenal products are important to the changes induced by ELV and whether or not reflux of left renal vein content occurs in the ELV rat. In the first study, testicular blood flow and temperature were studied in control animals and those with ELV, left adrenalectomy (LAX), or ELV + LAX. Control left and right testicular blood flow (33.6 +/- 0.8 and 33.6 +/- 1.5 ml./min./100 gm. tissue respectively) was significantly elevated by ELV (to 39.9 +/- 0.9 and 41.2 +/- 2.7 ml./min./100 gm. tissue, respectively) and the difference between abdominal and testicular temperatures (delta T) was significantly reduced. Control delta T's for right and left testes were 3.2 +/- 0.2C and 3.2 +/- 0.2C, respectively, and right and left delta T's for ELV animals were 2.0 +/- 0.3 degrees C and 2.0 +/- 0.3C, respectively. These blood flow and temperature changes also occurred when ELV animals were subjected to simultaneous LAX. Additionally, when 85Sr-labelled microspheres were infused intomore » the left renal vein, they did not appear in either left or right testes of ELV animals. We conclude that there is no evidence for reflux down the spermatic vein in ELV in rats and adrenal products do not reach the testis via this route after being secreted into the renal vein. We raise the suggestion that the same may be true in the human.« less

Authors:
;  [1]
  1. Univ. of Virginia School of Medicine, Charlottesville (USA)
Publication Date:
OSTI Identifier:
5129781
Resource Type:
Journal Article
Journal Name:
Journal of Urology; (USA)
Additional Journal Information:
Journal Volume: 142:5; Journal ID: ISSN 0022-5347
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; TESTES; BLOOD FLOW; VASCULAR DISEASES; PATHOGENESIS; ADRENAL GLANDS; BODY TEMPERATURE; MICROSPHERES; RATS; STRONTIUM 86; TRACER TECHNIQUES; VEINS; ALKALINE EARTH ISOTOPES; ANIMALS; BLOOD VESSELS; BODY; CARDIOVASCULAR SYSTEM; DISEASES; ENDOCRINE GLANDS; EVEN-EVEN NUCLEI; GLANDS; GONADS; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MALE GENITALS; MAMMALS; NUCLEI; ORGANS; RODENTS; STABLE ISOTOPES; STRONTIUM ISOTOPES; VERTEBRATES; 550901* - Pathology- Tracer Techniques

Citation Formats

Turner, T T, and Lopez, T J. Effects of experimental varicocele require neither adrenal contribution nor venous reflux. United States: N. p., 1989. Web.
Turner, T T, & Lopez, T J. Effects of experimental varicocele require neither adrenal contribution nor venous reflux. United States.
Turner, T T, and Lopez, T J. 1989. "Effects of experimental varicocele require neither adrenal contribution nor venous reflux". United States.
@article{osti_5129781,
title = {Effects of experimental varicocele require neither adrenal contribution nor venous reflux},
author = {Turner, T T and Lopez, T J},
abstractNote = {Experimental left varicocele (ELV) is known to induce bilateral changes in the rat testis that, where comparisons are possible, are similar to the changes induced by unilateral varicocele in the human. In the present study, we have determined whether or not left adrenal products are important to the changes induced by ELV and whether or not reflux of left renal vein content occurs in the ELV rat. In the first study, testicular blood flow and temperature were studied in control animals and those with ELV, left adrenalectomy (LAX), or ELV + LAX. Control left and right testicular blood flow (33.6 +/- 0.8 and 33.6 +/- 1.5 ml./min./100 gm. tissue respectively) was significantly elevated by ELV (to 39.9 +/- 0.9 and 41.2 +/- 2.7 ml./min./100 gm. tissue, respectively) and the difference between abdominal and testicular temperatures (delta T) was significantly reduced. Control delta T's for right and left testes were 3.2 +/- 0.2C and 3.2 +/- 0.2C, respectively, and right and left delta T's for ELV animals were 2.0 +/- 0.3 degrees C and 2.0 +/- 0.3C, respectively. These blood flow and temperature changes also occurred when ELV animals were subjected to simultaneous LAX. Additionally, when 85Sr-labelled microspheres were infused into the left renal vein, they did not appear in either left or right testes of ELV animals. We conclude that there is no evidence for reflux down the spermatic vein in ELV in rats and adrenal products do not reach the testis via this route after being secreted into the renal vein. We raise the suggestion that the same may be true in the human.},
doi = {},
url = {https://www.osti.gov/biblio/5129781}, journal = {Journal of Urology; (USA)},
issn = {0022-5347},
number = ,
volume = 142:5,
place = {United States},
year = {Wed Nov 01 00:00:00 EST 1989},
month = {Wed Nov 01 00:00:00 EST 1989}
}